Vaccine-associated attenuation of subjective severity among outpatients with influenza

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Chung, Jessie R. ; Kim, Sara S. ; Flannery, Brendan ; Smith, Michael E. ; Dunnigan, Kayan ; Raiyani, Chandni ; Murthy, Kempapura ; Gaglani, Manjusha ; Jackson, Michael L. ; Jackson, Lisa A. ; Bear, Todd ; Geffel, Krissy Moehling ; Nowalk, Mary Patricia ; Zimmerman, Richard K. ; Martin, Emily T. ; Lamerato, Lois ; McLean, Huong Q. ; King, Jennifer P. ; Belongia, Edward A. ; Thompson, Mark G. ; Patel, Manish
• Description:
  Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible.
• Subjects:
  Hospitalization Humans Influenza, Human Influenza Vaccines Outpatients Seasons Vaccination
• Source:
  Vaccine. 40(32):4322-4327
• Pubmed ID:
  35710506
• Pubmed Central ID:
  PMC9638984
• Document Type:
  Journal Article
• Funding:
  UL1 TR000005/TR/NCATS NIH HHSUnited States/ ; UL1 TR001857/TR/NCATS NIH HHSUnited States/ ; U01 IP000473/IP/NCIRD CDC HHSUnited States/ ; U01 IP000466/IP/NCIRD CDC HHSUnited States/ ; U01 IP001039/IP/NCIRD CDC HHSUnited States/ ; U01 IP000471/IP/NCIRD CDC HHSUnited States/ ; U01 IP000474/IP/NCIRD CDC HHSUnited States/ ; U01 IP000467/IP/NCIRD CDC HHSUnited States/ ; U01IP001039/ACL/ACL HHSUnited States/ ; U01 IP001034/IP/NCIRD CDC HHSUnited States/ ; UL1 RR024153/RR/NCRR NIH HHSUnited States/ ; U01 IP001035/IP/NCIRD CDC HHSUnited States/ ; U01 IP001037/IP/NCIRD CDC HHSUnited States/ ; U01 IP001038/IP/NCIRD CDC HHSUnited States/
• Volume:
  40
• Issue:
  32
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6c0f2ebe31a46539d15da2f26706869363a48f8e5cc493d8b5f8befabf5971f6
• Download URL:
  https://stacks.cdc.gov/view/cdc/122070/cdc_122070_DS1.pdf
• File Type:
  [PDF - 104.45 KB ]