Epidemiology of Invasive Haemophilus influenzae Serotype a Disease—United States, 2008–2017

Details

• Alternative Title:
  Clin Infect Dis
• Personal Author:
  Soeters, Heidi M. ; Oliver, Sara E. ; Plumb, Ian D. ; Blain, Amy E. ; Zulz, Tammy ; Simons, Brenna C. ; Barnes, Meghan ; Farley, Monica M. ; Harrison, Lee H. ; Lynfield, Ruth ; Massay, Stephanie ; McLaughlin, Joseph ; Muse, Alison G. ; Petit, Susan ; Schaffner, William ; Thomas, Ann ; Torres, Salina ; Watt, James ; Pondo, Tracy ; Whaley, Melissa J. ; Hu, Fang ; Wang, Xin ; Briere, Elizabeth C. ; Bruce, Michael G.
• Description:
  Background:
  
  Haemophilus influenzae serotype a (Hia) can cause invasive disease similar to serotype b; no Hia vaccine is available. We describe the epidemiology of invasive Hia disease in the United States overall and specifically in Alaska during 2008–2017.
  
  Methods:
  
  Active population- and laboratory-based surveillance for invasive Hia disease was conducted through Active Bacterial Core surveillance sites and from Alaska statewide invasive bacterial disease surveillance. Sterile-site isolates were serotyped via slide agglutination or real-time polymerase chain reaction. Incidences in cases per 100,000 were calculated.
  
  Results:
  
  From 2008–2017, an estimated average of 306 invasive Hia disease cases occurred annually in the United States (estimated annual incidence: 0.10); incidence increased by an average of 11.1% annually. Overall, 42.7% of cases were in children aged <5 years (incidence: 0.64), with highest incidence among children aged <1 year (1.60). Case fatality was 7.8% overall and was highest among adults aged ≥65 years (15.1%). Among children aged <5 years, incidence was 17 times higher among American Indians and Alaska Native (AI/AN) children (8.29) than among children of all other races combined (0.49). In Alaska, incidences among all ages (0.68) and among children aged <1 year (24.73) were nearly 6 and 14 times higher, respectively, than corresponding U.S. incidences. Case fatality in Alaska was 10.2%, and the vast majority (93.9%) of cases occurred among AI/AN.
  
  Conclusions:
  
  Incidence of invasive Hia disease has increased since 2008, with the highest burden among AI/AN children. These data can inform prevention strategies, including Hia vaccine development.
  
  
• Subjects:
  Adult Alaska Child Haemophilus Infections Haemophilus Influenzae Humans Incidence Serogroup Serotyping United States Vaccines, Conjugate

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• Keywords:
  American Indian And Alaska Native Bacterial Infections Epidemiology Invasive Disease Serotype A Surveillance
• Source:
  Clin Infect Dis. 73(2):e371-e379
• Pubmed ID:
  32589699
• Pubmed Central ID:
  PMC9628811
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  73
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:ecd2c8fde347a899b435a01a723a4d11cb0778192dce49efe5ade08b59b0ca49b2be8d9da7a8dc5c7ee26dd811b91118a429c3ae60d7c5eca85dc3805c9c7c51
• Download URL:
  https://stacks.cdc.gov/view/cdc/122053/cdc_122053_DS1.pdf
• File Type:
  [PDF - 548.17 KB ]