The Association of Physical Activity to Oral Glucose Tolerance Test Outcomes in Multiple Autoantibody Positive Children: The TEDDY Study

Details

• Alternative Title:
  Pediatr Diabetes
• Personal Author:
  Johnson, Suzanne Bennett ; Tamura, Roy ; McIver, Kerry L. ; Pate, Russell R. ; Driscoll, Kimberly A. ; Melin, Jessica ; Larsson, Helena Elding ; Haller, Michael J. ; Yang, Jimin
• Corporate Authors:
  TEDDY Study Group
• Description:
  Objective:
  
  To examine the association of physical activity (PA), measured by accelerometry, to hemoglobin AIC (HbA1c) and Oral Glucose Tolerance Test (OGTT) outcomes in children who were multiple persistent confirmed autoantibody positive for type 1 diabetes (T1D).
  
  Methods:
  
  The Environmental Determinants of Diabetes in the Young (TEDDY) multinational study followed children from birth. Children ≥ 3 years of age who were multiple persistent confirmed autoantibody positive were monitored by OGTTs every 6 months. TEDDY children’s PA was measured by accelerometry beginning at 5 years of age. We examined the relationship between moderate plus vigorous (mod+vig) PA, HbA1c, and OGTT in 209 multiple autoantibody children who had both OGTT and PA measurements.
  
  Results:
  
  Mod+vig PA was associated with both glucose and C-peptide measures (fasting, 120-minute, and AUC); higher mod+vig PA was associated with a better OGTT response primarily in children with longer duration of multiple autoantibody positivity. Mod+vig PA also interacted with child age; lower mod+vig PA was associated with a greater increase in C-peptide response across age. Mod+vig PA was not related to fasting insulin, HOMA-IR or HbA1c.
  
  Conclusions:
  
  The OGTT is the gold standard for diabetes diagnosis and is used to monitor those at high risk for T1D. We found higher levels of mod+vig PA were associated with better OGTT outcomes in children ≥ 5 years of age who have been multiple autoantibody positive for longer periods of time. Physical activity should be the focus of future efforts to better understand the determinants of disease progression in high-risk children.
  
  
• Subjects:
  Article Autoantibodies Blood Glucose C-Peptide Child Diabetes Mellitus, Type 1 Exercise Glucose Glucose Tolerance Test Glycated Hemoglobin A Humans Infant Multiple Autoantibody Positive OGTT Physical Activity

  More +
• Source:
  Pediatr Diabetes. 23(7):1017-1026
• Pubmed ID:
  35702057
• Pubmed Central ID:
  PMC9588568
• Document Type:
  Journal Article
• Funding:
  U01 DK063821/DK/NIDDK NIH HHSUnited States/ ; UC4 DK063863/DK/NIDDK NIH HHSUnited States/ ; UL1 TR002535/TR/NCATS NIH HHSUnited States/ ; U01 DK063790/DK/NIDDK NIH HHSUnited States/ ; NH/NIH HHSUnited States/ ; HHSN267200700014C/DK/NIDDK NIH HHSUnited States/ ; CC/CDC HHSUnited States/ ; UL1 TR000064/TR/NCATS NIH HHSUnited States/ ; U01 DK063836/DK/NIDDK NIH HHSUnited States/ ; Juvenile Diabetes Research Foundation International/ ; National Institute of Allergy and Infectious Diseases/ ; U01 DK063829/DK/NIDDK NIH HHSUnited States/ ; U01 DK063865/DK/NIDDK NIH HHSUnited States/ ; UC4 DK095300/DK/NIDDK NIH HHSUnited States/ ; UC4 DK063861/DK/NIDDK NIH HHSUnited States/ ; UC4 DK063829/DK/NIDDK NIH HHSUnited States/ ; ES/NIEHS NIH HHSUnited States/ ; UC4 DK063821/DK/NIDDK NIH HHSUnited States/ ; UC4 DK117483/DK/NIDDK NIH HHSUnited States/ ; UC4 DK063836/DK/NIDDK NIH HHSUnited States/ ; UC4 DK112243/DK/NIDDK NIH HHSUnited States/ ; U01 DK124166/DK/NIDDK NIH HHSUnited States/ ; U01 DK063861/DK/NIDDK NIH HHSUnited States/ ; Division of Intramural Research, National Institute of Allergy and Infectious Diseases/ ; U01 DK128847/DK/NIDDK NIH HHSUnited States/ ; UC4 DK063865/DK/NIDDK NIH HHSUnited States/ ; U01 DK063863/DK/NIDDK NIH HHSUnited States/ ; Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; UC4 DK106955/DK/NIDDK NIH HHSUnited States/ ; UC4 DK100238/DK/NIDDK NIH HHSUnited States/
• Volume:
  23
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0756a5bd7b1dc3765b68196981f40b24b860b14789cd43e3c9438f79d5f00220
• Download URL:
  https://stacks.cdc.gov/view/cdc/121913/cdc_121913_DS1.pdf
• File Type:
  [PDF - 327.27 KB ]