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PERFORMANCE OF A1C VERSUS OGTT FOR THE DIAGNOSIS OF PREDIABETES IN A COMMUNITY-BASED SCREENING
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Details:
  • Pubmed ID:
    27482613
  • Pubmed Central ID:
    PMC5278882
  • Funding:
    H75 DP002861/DP/NCCDPHP CDC HHS/United States
    P20 GM103451/GM/NIGMS NIH HHS/United States
    P20 RR016480/RR/NCRR NIH HHS/United States
    UL1 TR000041/TR/NCATS NIH HHS/United States
  • Document Type:
  • Collection(s):
  • Description:
    Objective

    Reliable identification of individuals at risk for developing diabetes is critical to instituting preventative strategies. Studies suggest that the accuracy of using A1c as a sole diagnostic criterion for diabetes may be variable across different ethnic groups. We postulate that there will be lack of concordance between A1c and the Oral Glucose Tolerance Test (OGTT) for diagnosing prediabetes across Hispanic and Non-Hispanic White (NHW) populations.

    Research Design and Methods

    218 asymptomatic adults at risk for Type 2 Diabetes (T2D) were assessed with A1c and OGTT for the diagnosis of prediabetes. Glucose homeostasis status was assigned as no diabetes (A1c < 5.7%), prediabetes (A1c 5.7% – 6.4%), and T2D (A1c > 6.4%). Inclusion criteria were age > 18 years and at least one of the following: a family history of diabetes, a history of gestational diabetes, Hispanic ethnicity, non-Caucasian race, or obesity. Subjects received a fasting 75-gram OGTT and A1c on the same day. Bowker’s Test of Symmetry was employed to determine agreement between the tests.

    Results

    Data from 99 Hispanic patients and 79 NHW patients were analyzed. There was no concordance between A1c and OGTT for Hispanic (p=0.002) or NHW individuals (p=0.003) with prediabetes.

    Conclusions

    A1c is discordant with OGTT among Hispanic and NHW subjects for the diagnosis of prediabetes. Sole use of A1c to designate glycemic status will result in a greater prevalence of prediabetes among Hispanic and NHW New Mexicans.