First Trimester Plasma Glucose Values in Non-Diabetic Women are Associated with Risk for Congenital Heart Disease in Offspring

Details

• Alternative Title:
  J Pediatr
• Personal Author:
  Helle, Emmi I.T. ; Biegley, Preston ; Knowles, Joshua W. ; Leader, Joseph B. ; Pendergrass, Sarah ; Yang, Wei ; Reaven, Gerald R ; Shaw, Gary M. ; Ritchie, Marylyn ; Priest, James R.
• Description:
  In a retrospective study of 19 171 mother-child dyads, elevated random plasma glucose values during early pregnancy were directly correlated with increased risk for congenital heart disease in offspring. Plasma glucose levels proximal to the period of cardiac development may represent a modifiable risk factor for congenital heart disease in expectant mothers without diabetes.
• Subjects:
  • Adolescent
  • Adult
  • Biomarkers
  • Blood Glucose
  • Female
  • Heart Defects, Congenital
  • Humans
  • Hyperglycemia
  • Infant, Newborn
  • Pregnancy
  More +
• Keywords:
  • congenital heart disease
  • congenital malformation
  • plasma glucose
  • diabetes
  • oral glucose tolerance test
• Source:
  J Pediatr. 195:275-278
• Pubmed ID:
  29254757
• Pubmed Central ID:
  PMC5869072
• Document Type:
  Journal Article
• Funding:
  2016097/DDCF/Doris Duke Charitable FoundationUnited States/ ; U01 DD001033/DD/NCBDD CDC HHSUnited States/ ; U01DD001033/ACL/ACL HHSUnited States/ ; P30 DK116074/DK/NIDDK NIH HHSUnited States/ ; K99 HL130523/HL/NHLBI NIH HHSUnited States/ ; R00 HL130523/HL/NHLBI NIH HHSUnited States/
• Volume:
  195
• Download URL:
  https://stacks.cdc.gov/view/cdc/52940/cdc_52940_DS1.pdf
• File Type:
  [PDF - 53.00 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:427cf59fa18865d52775eddbdc118bef903ad8df8c0ffb6bb668a55b76c62b2f