First Trimester Plasma Glucose Values in Non-Diabetic Women are Associated with Risk for Congenital Heart Disease in Offspring

Details

• Alternative Title:
  J Pediatr
• Personal Author:
  Helle, Emmi I.T. ; Biegley, Preston ; Knowles, Joshua W. ; Leader, Joseph B. ; Pendergrass, Sarah ; Yang, Wei ; Reaven, Gerald R ; Shaw, Gary M. ; Ritchie, Marylyn ; Priest, James R.
• Description:
  In a retrospective study of 19 171 mother-child dyads, elevated random plasma glucose values during early pregnancy were directly correlated with increased risk for congenital heart disease in offspring. Plasma glucose levels proximal to the period of cardiac development may represent a modifiable risk factor for congenital heart disease in expectant mothers without diabetes.
• Subjects:
  Adolescent Adult Biomarkers Blood Glucose Female Heart Defects, Congenital Humans Hyperglycemia Infant, Newborn Pregnancy Pregnancy Complications Pregnancy Trimester, First Retrospective Studies Risk Factors Young Adult

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• Keywords:
  Congenital Heart Disease Congenital Malformation Diabetes Oral Glucose Tolerance Test Plasma Glucose
• Source:
  J Pediatr. 195:275-278
• Pubmed ID:
  29254757
• Pubmed Central ID:
  PMC5869072
• Document Type:
  Journal Article
• Funding:
  2016097/DDCF/Doris Duke Charitable FoundationUnited States/ ; U01 DD001033/DD/NCBDD CDC HHSUnited States/ ; U01DD001033/ACL/ACL HHSUnited States/ ; P30 DK116074/DK/NIDDK NIH HHSUnited States/ ; K99 HL130523/HL/NHLBI NIH HHSUnited States/ ; R00 HL130523/HL/NHLBI NIH HHSUnited States/
• Volume:
  195
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:427cf59fa18865d52775eddbdc118bef903ad8df8c0ffb6bb668a55b76c62b2f
• Download URL:
  https://stacks.cdc.gov/view/cdc/52940/cdc_52940_DS1.pdf
• File Type:
  [PDF - 53.00 KB ]