Air pollution and dementia in older adults in the Ginkgo Evaluation of Memory Study

Details

• Alternative Title:
  Alzheimers Dement
• Personal Author:
  Semmens, Erin O. ; Leary, Cindy S. ; Fitzpatrick, Annette L. ; Ilango, Sindana D. ; Park, Christina ; Adam, Claire E. ; DeKosky, Steven T. ; Lopez, Oscar ; Hajat, Anjum ; Kaufman, Joel D.
• Description:
  Introduction:
  
  Growing evidence implicates air pollution as a risk factor for dementia, but prior work is limited by challenges in diagnostic accuracy and assessing exposures in the decades prior to disease development. We evaluated the impact of long-term fine particulate matter (PM2.5) exposures on incident dementia (all-cause, Alzheimer’s disease [AD], and vascular dementia [VaD]) in older adults.
  
  Methods:
  
  A panel of neurologists adjudicated dementia cases based on extensive neuropsychological testing and magnetic resonance imaging. We applied validated fine-scale air pollutant models to reconstructed residential histories to assess exposures.
  
  Results:
  
  An interquartile range increase in 20-year PM2.5 was associated with a 20% higher risk of dementia (95% confidence interval [CI]: 5%, 37%) and an increased risk of mixed VaD/AD but not AD alone.
  
  Discussion:
  
  Our findings suggest that air pollutant exposures over decades contribute to dementia and that effects of current exposures may be experienced years into the future.
  
  
• Subjects:
  Aged Air Pollutants Air Pollution Alzheimer Disease Dementia, Vascular Ginkgo Biloba Humans Particulate Matter
• Keywords:
  Air Pollution Alzheimer's Disease Alzheimer's Disease Sequencing Project Alzheimer’s Disease Antiviral Agents Dementia Herpes Simplex Human Papillomavirus Longitudinal Cohort Study Torque Teno Viruses Vascular Dementia Whole Exome Sequencing Whole Genome Sequencing

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• Source:
  Alzheimers Dement. 19(2):549-559
• Pubmed ID:
  35436383
• Pubmed Central ID:
  PMC9576823
• Document Type:
  Journal Article
• Funding:
  U01 AT000162/AT/NCCIH NIH HHSUnited States/ ; U01 HL130114/HL/NHLBI NIH HHSUnited States/ ; D43 TW011596/TW/FIC NIH HHSUnited States/ ; R00 ES023498/ES/NIEHS NIH HHSUnited States/ ; R01 AG058969/AG/NIA NIH HHSUnited States/ ; U19 AG057377/AG/NIA NIH HHSUnited States/ ; P30 AG066468/AG/NIA NIH HHSUnited States/ ; R21 OH011385/OH/NIOSH CDC HHSUnited States/ ; R03 ES019261/ES/NIEHS NIH HHSUnited States/ ; RF1 AG057033/AG/NIA NIH HHSUnited States/ ; T32 ES015459/ES/NIEHS NIH HHSUnited States/ ; P30 ES007033/ES/NIEHS NIH HHSUnited States/ ; UG1 OD024952/OD/NIH HHSUnited States/ ; R01 AG059727/AG/NIA NIH HHSUnited States/ ; P50 AG005133/AG/NIA NIH HHSUnited States/ ; P20 GM130418/GM/NIGMS NIH HHSUnited States/ ; R01 AG060011/AG/NIA NIH HHSUnited States/
• Volume:
  19
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:33241a8bcaa3ab38f63a7d674d8a8e397c0f22f1c5fe5b175ec9fa74b557dda9ef6defda0448486592a13587288e3c17394e77f58f257131903a0c54258987b8
• Download URL:
  https://stacks.cdc.gov/view/cdc/121849/cdc_121849_DS1.pdf
• File Type:
  [PDF - 891.17 KB ]