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Air pollution and dementia in older adults in the Ginkgo Evaluation of Memory Study
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4 18 2022
Source: Alzheimers Dement. 19(2):549-559 -
Alternative Title:Alzheimers Dement
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Description:Introduction:
Growing evidence implicates air pollution as a risk factor for dementia, but prior work is limited by challenges in diagnostic accuracy and assessing exposures in the decades prior to disease development. We evaluated the impact of long-term fine particulate matter (PM2.5) exposures on incident dementia (all-cause, Alzheimer’s disease [AD], and vascular dementia [VaD]) in older adults.
Methods:
A panel of neurologists adjudicated dementia cases based on extensive neuropsychological testing and magnetic resonance imaging. We applied validated fine-scale air pollutant models to reconstructed residential histories to assess exposures.
Results:
An interquartile range increase in 20-year PM2.5 was associated with a 20% higher risk of dementia (95% confidence interval [CI]: 5%, 37%) and an increased risk of mixed VaD/AD but not AD alone.
Discussion:
Our findings suggest that air pollutant exposures over decades contribute to dementia and that effects of current exposures may be experienced years into the future.
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Pubmed ID:35436383
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Pubmed Central ID:PMC9576823
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