DNA from multiple viral species are associated with Alzheimer’s disease risk

Tejeda, Marlene; Farrell, John; Zhu, Congcong; Wetzler, Lee; Lunetta, Kathryn L.; Bush, William S.; Martin, Eden R.; Wang, Li-San; Schellenberg, Gerard; Pericak-Vance, Margaret A.; Haines, Jonathan L.; Farrer, Lindsay A.; Sherva, Richard

doi:10.1002/alz.13414

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DNA from multiple viral species are associated with Alzheimer’s disease risk

1 2024
By Tejeda, Marlene ; Farrell, John ; Zhu, Congcong ; ...
Source: Alzheimers Dement. 20(1):253-265

Public Access Version Available on: January 01, 2025, 12:00 AM

Please check back on the date listed above.

English

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Details:

Alternative Title:

Alzheimers Dement
Personal Author:

Tejeda, Marlene ; Farrell, John ; Zhu, Congcong ; Wetzler, Lee ; Lunetta, Kathryn L. ; ... More +

Tejeda, Marlene ; Farrell, John ; Zhu, Congcong ; Wetzler, Lee ; Lunetta, Kathryn L. ; Bush, William S. ; Martin, Eden R. ; Wang, Li-San ; Schellenberg, Gerard ; Pericak-Vance, Margaret A. ; Haines, Jonathan L. ; Farrer, Lindsay A. ; Sherva, Richard Less -
Description:

INTRODUCTION:

Multiple infectious agents, including viruses, bacteria, fungi, and protozoa, have been linked to Alzheimer disease (AD) risk by independent lines of evidence. We explored this association by comparing the frequencies of viral species identified in a large sample of AD cases and controls.

METHODS:

DNA sequence reads that did not align to the human genome in sequences were mapped to viral reference sequences, quantified, and then were tested for association with AD in whole exome sequences (WES) and whole genome sequences (WGS) datasets.

RESULTS:

Several viruses were significant predictors of AD according to the machine learning classifiers. Subsequent regression analyses showed that HSV-1 (OR=3.71, P=8.03×10−4) and HPV-71(OR=3.56, P=0.02), were significantly associated with AD after Bonferroni correction. The phylogenetic-related cluster of Herpesviridae was significantly associated with AD in several strata of the data (P<0.01).

DISCUSSION:

Our results support the hypothesis that viral infection, especially HSV-1, is associated with AD risk.
Keywords:

[+]

Alzheimer Disease Alzheimer’s Disease Alzheimer’s Disease Sequencing Project Antiviral Agents DNA Herpes Simplex Herpesvirus 1, Human Human Papillomavirus Humans Phylogeny Torque Teno Viruses Whole Exome Sequencing Whole Genome Sequencing
Source:

Alzheimers Dement. 20(1):253-265
Pubmed ID:

37578203
Pubmed Central ID:

PMC10840621
Document Type:

Journal Article
Funding:

HHSN268201100012C/HL/NHLBI NIH HHSUnited States/ ; P20 AG068082/AG/NIA NIH HHSUnited States/ ; P30 AG072975/AG/NIA NIH HHSUnited States/ ; R01 AG042188/AG/NIA NIH HHSUnited States/ ; P30 AG066444/AG/NIA NIH HHSUnited States/ ; ... More +

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N01HC85083/HL/NHLBI NIH HHSUnited States/ ; R01 AG027944/AG/NIA NIH HHSUnited States/ ; HHSN268201100005C/HL/NHLBI NIH HHSUnited States/ ; N01HC25195/HL/NHLBI NIH HHSUnited States/ ; P20 AG068024/AG/NIA NIH HHSUnited States/ ; P30 AG072958/AG/NIA NIH HHSUnited States/ ; R01 AG025259/AG/NIA NIH HHSUnited States/ ; RF1 AG057519/AG/NIA NIH HHSUnited States/ ; U01 HL096899/HL/NHLBI NIH HHSUnited States/ ; HHSN268201100007I/HL/NHLBI NIH HHSUnited States/ ; P30 AG062715/AG/NIA NIH HHSUnited States/ ; RF1 AG015473/AG/NIA NIH HHSUnited States/ ; U01 AG049506/AG/NIA NIH HHSUnited States/ ; P30 AG066506/AG/NIA NIH HHSUnited States/ ; P30 AG072976/AG/NIA NIH HHSUnited States/ ; WT_/Wellcome TrustUnited Kingdom/ ; R01 AG011101/AG/NIA NIH HHSUnited States/ ; P30 AG066468/AG/NIA NIH HHSUnited States/ ; R01 AG021136/AG/NIA NIH HHSUnited States/ ; P30 AG072931/AG/NIA NIH HHSUnited States/ ; P30 AG072947/AG/NIA NIH HHSUnited States/ ; U01 AG058635/AG/NIA NIH HHSUnited States/ ; RF1 AG057519/NH/NIH HHSUnited States/ ; N01HC85079/HL/NHLBI NIH HHSUnited States/ ; P30 AG072972/AG/NIA NIH HHSUnited States/ ; R01 AG023629/AG/NIA NIH HHSUnited States/ ; P30 AG066514/AG/NIA NIH HHSUnited States/ ; U19 AG066567/AG/NIA NIH HHSUnited States/ ; N01HC85080/HL/NHLBI NIH HHSUnited States/ ; P30 AG072959/AG/NIA NIH HHSUnited States/ ; R01 AG031272/AG/NIA NIH HHSUnited States/ ; R01 AG011380/AG/NIA NIH HHSUnited States/ ; P50 NS071674/NS/NINDS NIH HHSUnited States/ ; U19 AG068753/AG/NIA NIH HHSUnited States/ ; P30 AG072979/AG/NIA NIH HHSUnited States/ ; RF1 AG058267/AG/NIA NIH HHSUnited States/ ; R01 AG015819/AG/NIA NIH HHSUnited States/ ; N01HC85081/HL/NHLBI NIH HHSUnited States/ ; U01 AG062602/NH/NIH HHSUnited States/ ; U01 AG049505/AG/NIA NIH HHSUnited States/ Less -
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urn:sha256:200b0db3b6e8d8d96ac9b5c956dacf075177059624cbfdcbdec21d9ff44823c3
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