Longitudinal SARS-CoV-2 Nucleocapsid Antibody Kinetics, Seroreversion, and Implications for Seroepidemiologic Studies

Loesche, Michael; Karlson, Elizabeth W.; Talabi, Opeyemi; Zhou, Guohai; Boutin, Natalie; Atchley, Rachel; Loevinsohn, Gideon; Chang, Jun Bai Park; Hasdianda, Mohammad A.; Okenla, Adetoun; Sampson, Elizabeth; Schram, Haley; Magsipoc, Karen; Goodman, Kirsten; Donahue, Lauren; MacGowan, Maureen; Novack, Lewis A.; Jarolim, Petr; Baden, Lindsey R.; Nilles, Eric J.

doi:10.3201/eid2809.220729

i

Longitudinal SARS-CoV-2 Nucleocapsid Antibody Kinetics, Seroreversion, and Implications for Seroepidemiologic Studies

Supporting Files Public Domain

9 2022
By Loesche, Michael ; Karlson, Elizabeth W. ; Talabi, Opeyemi
http://dx.doi.org/10.3201/eid2809.220729

File Language:

English

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Alternative Title:

Emerg Infect Dis
Personal Author:

Loesche, Michael ; Karlson, Elizabeth W. ; Talabi, Opeyemi ; Zhou, Guohai ; Boutin, Natalie ; Atchley, Rachel ; Loevinsohn, Gideon ; Chang, Jun Bai Park ; Hasdianda, Mohammad A. ; Okenla, Adetoun ; Sampson, Elizabeth ; Schram, Haley ; Magsipoc, Karen ; Goodman, Kirsten ; Donahue, Lauren ; MacGowan, Maureen ; Novack, Lewis A. ; Jarolim, Petr ; Baden, Lindsey R. ; Nilles, Eric J.
Description:

Given widespread use of spike antibody in generating coronavirus disease vaccines, SARS-CoV-2 nucleocapsid antibodies are increasingly used to indicate previous infection in serologic surveys. However, longitudinal kinetics and seroreversion are poorly defined. We found substantial seroreversion of nucleocapsid total immunoglobulin, underscoring the need to account for seroreversion in seroepidemiologic studies.
Subjects:
Source:

Emerg Infect Dis. 2022; 28(9):1859-1862
Pubmed ID:

35868337
Pubmed Central ID:

PMC9423917
Document Type:

Journal Article
Volume:

28
Issue:

9
Download URL:

https://stacks.cdc.gov/view/cdc/121059/cdc_121059_DS1.pdf
File Type:

[PDF - 959.47 KB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:5293b59a4f220bd785e6637f1f7c9a4ae8a098f32c86c2348c28ecbdc85e9200

File Language:

English

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