Variant-specific burden of SARS-CoV-2 in Michigan: March 2020 through November 2021

Details

• Alternative Title:
  J Med Virol
• Personal Author:
  Petrie, Joshua G. ; Eisenberg, Marisa C. ; Lauring, Adam S. ; Gilbert, Julie ; Harrison, Samantha M. ; DeJonge, Peter M. ; Martin, Emily T.
• Description:
  Objectives:
  
  Accurate estimates of total burden of SARS-CoV-2 are needed to inform policy, planning and response. We sought to quantify SARS-CoV-2 cases, hospitalizations, and deaths by age in Michigan.
  
  Methods:
  
  COVID-19 cases reported to the Michigan Disease Surveillance System were multiplied by age and time-specific adjustment factors to correct for under-detection. Adjustment factors were estimated in a model fit to incidence data and seroprevalence estimates. Age-specific incidence of SARS-CoV-2 hospitalization, death, and vaccination, and variant proportions were estimated from publicly available data.
  
  Results:
  
  We estimated substantial under-detection of infection that varied by age and time. Accounting for under-detection, we estimate cumulative incidence of infection in Michigan reached 75% by mid-November 2021, and over 87% of Michigan residents were estimated to have had ≥1 vaccination dose and/or previous infection. Comparing pandemic waves, the relative burden among children increased over time. In general, the proportion of cases who were hospitalized or who died decreased over time.
  
  Conclusions:
  
  Our results highlight the ongoing risk of periods of high SARS-CoV-2 incidence despite widespread prior infection and vaccination. This underscores the need for long-term planning for surveillance, vaccination, and other mitigation measures amidst continued response to the acute pandemic.
  
  
• Subjects:
  Child COVID-19 Humans Michigan Pandemics SARS-CoV-2 Seroepidemiologic Studies
• Keywords:
  Case Fatality Incidence Infection Seroprevalence
• Source:
  J Med Virol. 94(11):5251-5259
• Pubmed ID:
  35798681
• Pubmed Central ID:
  PMC9350192
• Document Type:
  Journal Article
• Funding:
  K01 AI141579/AI/NIAID NIH HHSUnited States/ ; NH/NIH HHSUnited States/ ; CC/CDC HHSUnited States/
• Volume:
  94
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:a11e3f197f31a58b327b685089eab056506b804094f8d7e0158fbb5904579d5d25a622c3265be6edf88efb2bace54b65a43c2f12675c6dd39ebecb471c4e25ac
• Download URL:
  https://stacks.cdc.gov/view/cdc/121198/cdc_121198_DS1.pdf
• File Type:
  [PDF - 1.51 MB ]