Details:

Alternative Title:
J Med Virol
Publisher's site:
http://dx.doi.org/10.1002/jmv.27982
Personal Author:
Petrie, Joshua G. ; Eisenberg, Marisa C. ; Lauring, Adam S. ; Gilbert, Julie ; Harrison, Samantha M. ; ... More +
Petrie, Joshua G. ; Eisenberg, Marisa C. ; Lauring, Adam S. ; Gilbert, Julie ; Harrison, Samantha M. ; DeJonge, Peter M. ; Martin, Emily T. Less -
Description:
Objectives:

Accurate estimates of total burden of SARS-CoV-2 are needed to inform policy, planning and response. We sought to quantify SARS-CoV-2 cases, hospitalizations, and deaths by age in Michigan.

Methods:

COVID-19 cases reported to the Michigan Disease Surveillance System were multiplied by age and time-specific adjustment factors to correct for under-detection. Adjustment factors were estimated in a model fit to incidence data and seroprevalence estimates. Age-specific incidence of SARS-CoV-2 hospitalization, death, and vaccination, and variant proportions were estimated from publicly available data.

Results:

We estimated substantial under-detection of infection that varied by age and time. Accounting for under-detection, we estimate cumulative incidence of infection in Michigan reached 75% by mid-November 2021, and over 87% of Michigan residents were estimated to have had ≥1 vaccination dose and/or previous infection. Comparing pandemic waves, the relative burden among children increased over time. In general, the proportion of cases who were hospitalized or who died decreased over time.

Conclusions:

Our results highlight the ongoing risk of periods of high SARS-CoV-2 incidence despite widespread prior infection and vaccination. This underscores the need for long-term planning for surveillance, vaccination, and other mitigation measures amidst continued response to the acute pandemic.


Subjects:
[+]
Article Case Fatality Child COVID-19 Humans Incidence Infection Michigan Pandemics SARS-CoV-2 Seroepidemiologic Studies Seroprevalence
Source:
J Med Virol. 94(11):5251-5259
Pubmed ID:
35798681
Pubmed Central ID:
PMC9350192
Document Type:
Journal Article
Funding:
K01 AI141579/AI/NIAID NIH HHSUnited States/ ; NH/NIH HHSUnited States/ ; CC/CDC HHSUnited States/
K01 AI141579/AI/NIAID NIH HHSUnited States/ ; NH/NIH HHSUnited States/ ; CC/CDC HHSUnited States/ Less -
Place as Subject:
Michigan ; United States
Michigan ; United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:1f4060601b658fb1cf9ff4c4c9c060de1fe9c6a5b463c5d02459b081f9871297
File Type:

• Supporting Files:
  No Additional Files

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