Revised Definitions of Tuberculosis Resistance and Treatment Outcomes, France, 2006–2019

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Kherabi, Yousra ; Fréchet-Jachym, Mathilde ; Rioux, Christophe ; Yazdanpanah, Yazdan ; Méchaï, Frédéric ; Pourcher, Valérie ; Robert, Jérôme ; Guglielmetti, Lorenzo
• Corporate Authors:
  for the MDR-TB Management Group
• Description:
  Definitions of resistance in multidrug-resistant tuberculosis (MDR TB) and extensively drug-resistant tuberculosis (XDR TB) have been updated. Pre-XDR TB, defined as MDR TB with additional resistance to fluoroquinolones, and XDR TB, with additional resistance to bedaquiline or linezolid, are frequently associated with treatment failure and toxicity. We retrospectively determined the effects of pre-XDR/XDR TB resistance on outcomes and safety of MDR TB treatment in France. The study included 298 patients treated for MDR TB at 3 reference centers during 2006-2019. Of those, 205 (68.8%) cases were fluoroquinolone-susceptible MDR TB and 93 (31.2%) were pre-XDR/XDR TB. Compared with fluoroquinolone-susceptible MDR TB, pre-XDR/XDR TB was associated with more cavitary lung lesions and bilateral disease and required longer treatment. Overall, 202 patients (67.8%) had favorable treatment outcomes, with no significant difference between pre-XDR/XDR TB (67.7%) and fluoroquinolone-susceptible MDR TB (67.8%; p = 0.99). Pre-XDR/XDR TB was not associated with higher risk for serious adverse events.
• Subjects:
  Antitubercular Agents Extensively Drug-Resistant Tuberculosis Fluoroquinolones Humans Mycobacterium Tuberculosis Retrospective Studies Treatment Outcome Tuberculosis, Multidrug-Resistant
• Source:
  Emerg Infect Dis. 2022; 28(9):1796-1804
• Pubmed ID:
  35997386
• Pubmed Central ID:
  PMC9423894
• Document Type:
  Journal Article
• Place as Subject:
  France
• Volume:
  28
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:aa314dc2a4b225f61df38f02021ffef3db406bb9d91e0ca0bfa1ba3936ee6348
• Download URL:
  https://stacks.cdc.gov/view/cdc/121049/cdc_121049_DS1.pdf
• File Type:
  [PDF - 604.32 KB ]