Fetal Loss and Preterm Birth Caused by Intraamniotic Haemophilus influenzae Infection, New Zealand

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Hills, Thomas ; Sharpe, Caitlin ; Wong, Thomas ; Cutfield, Tim ; Lee, Arier ; McBride, Stephen ; Rogers, Matthew ; Soh, May Ching ; Taylor, Amanda ; Taylor, Susan ; Thomas, Mark
• Description:
  Invasive Haemophilus influenzae infection during pregnancy can cause preterm birth and fetal loss, but the mechanism is unclear. We investigated 54 cases of pregnancy-associated invasive H. influenzae disease in 52 unique pregnancies in the Auckland region of New Zealand during October 1, 2008‒September 30, 2018. Intraamniotic infection was identified in 36 (66.7%) of 54 cases. Outcome data were available for 48 pregnancies. Adverse pregnancy outcomes, defined as fetal loss, preterm birth, or the birth of an infant requiring intensive/special care unit admission, occurred in 45 (93.8%) of 48 (pregnancies. Fetal loss occurred in 17 (35.4%) of 48 pregnancies, before 24 weeks' gestation in 13 cases, and at >24 weeks' gestation in 4 cases. The overall incidence of pregnancy-associated invasive H. influenzae disease was 19.9 cases/100,000 births, which exceeded the reported incidence of pregnancy-associated listeriosis in New Zealand. We also observed higher rates in younger women and women of Māori ethnicity.
• Subjects:
  Female Gestational Age Haemophilus Infections Humans Infant, Newborn Pregnancy Pregnancy Outcome Premature Birth
• Source:
  Emerg Infect Dis. 2022; 28(9):1747-1754
• Pubmed ID:
  35997306
• Pubmed Central ID:
  PMC9423897
• Document Type:
  Journal Article
• Place as Subject:
  New Zealand
• Volume:
  28
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e566ede5c185d8a3939ffb694c8ba648b458e46f0c471a186b9fd6b881b6e713
• Download URL:
  https://stacks.cdc.gov/view/cdc/121043/cdc_121043_DS1.pdf
• File Type:
  [PDF - 835.92 KB ]