Characterization of Emerging Serotype 19A Pneumococcal Strains in Invasive Disease and Carriage, Belgium

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Desmet, Stefanie ; Theeten, Heidi ; Laenen, Lies ; Cuypers, Lize ; Maes, Piet ; Bossuyt, Wouter ; Van Heirstraeten, Liesbet ; Peetermans, Willy E. ; Lagrou, Katrien
• Description:
  After switching from 13-valent to 10-valent pneumococcal conjugate vaccine (PCV10) (2015-2016) for children in Belgium, we observed rapid reemergence of serotype 19A invasive pneumococcal disease (IPD). Whole-genome sequencing of 166 serotype 19A IPD isolates from children (n = 54) and older adults (n = 56) and carriage isolates from healthy children (n = 56) collected after the vaccine switch (2017-2018) showed 24 sequence types (STs). ST416 (global pneumococcal sequence cluster [GPSC] 4) and ST994 (GPSC146) accounted for 75.9% of IPD strains from children and 65.7% of IPD (children and older adults) and carriage isolates in the PCV10 period (2017-2018). These STs differed from predominant 19A IPD STs after introduction of PCV7 (2011) in Belgium (ST193 [GPSC11] and ST276 [GPSC10]), which indicates that prediction of emerging strains cannot be based solely on historical emerging strains. Despite their susceptible antimicrobial drug profiles, these clones spread in carriage and IPD during PCV10 use.
• Subjects:
  Aged Anti-Infective Agents Child Humans Infant Pneumococcal Infections Pneumococcal Vaccines Serogroup
• Source:
  Emerg Infect Dis. 2022; 28(8):1606-1614
• Pubmed ID:
  35876488
• Pubmed Central ID:
  PMC9328928
• Document Type:
  Journal Article
• Place as Subject:
  Belgium
• Volume:
  28
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:637e2b0c3d3e306ef1f6ffbcaccaf666edb2d138acff3968f2a5bdb005e1d26b
• Download URL:
  https://stacks.cdc.gov/view/cdc/120180/cdc_120180_DS1.pdf
• File Type:
  [PDF - 1.06 MB ]