Cancer risk in living kidney donors

Details

• Alternative Title:
  Am J Transplant
• Personal Author:
  Engels, Eric A. ; Fraser, Gary E. ; Kasiske, Bertram L. ; Snyder, Jon J. ; Utt, Jason ; Lynch, Charles F. ; Li, Jie ; Pawlish, Karen S. ; Brown, Sandra ; Yu, Kelly J. ; Pfeiffer, Ruth M.
• Description:
  Living kidney donors are screened for transmissible diseases including cancer. Outcomes following donation are excellent, but concern exists regarding development of chronic kidney disease, and cancer risk is unknown. We used linked transplant and cancer registry data to identify incident cancers among 84,357 kidney donors in the United States (1995-2017). We compared risk with the general population using standardized incidence ratios (SIRs). For selected cancers, we used Poisson regression to compare donors with 47,451 Adventist Health Study 2 (AHS-2) participants, who typically have healthy lifestyles. During follow-up, 2843 cancers were diagnosed in donors, representing an overall deficit (SIR 0.79, 95%CI 0.76-0.82). None of 46 specified cancer sites occurred in excess relative to the general population, and 15 showed significant deficits (SIR < 1.00). Compared with AHS-2 participants, donors had similar incidence of liver cancer, melanoma, breast cancer, and non-Hodgkin lymphoma but, starting 7 years after donation, elevated incidence of colorectal cancer (adjusted incidence rate ratio 2.07, 95%CI 1.54-2.79) and kidney cancer (2.97, 1.58-5.58, accounting for the presence of a single kidney in donors). Elevated kidney cancer incidence may reflect adverse processes in donors' remaining kidney. Nonetheless, cancer risk is lower than in the general population, suggesting that enhanced screening is unnecessary.
• Subjects:
  Humans Incidence Kidney Kidney Neoplasms Kidney Transplantation Living Donors Registries Risk Risk Factors United States
• Source:
  Am J Transplant. 22(8):2006-2015
• Pubmed ID:
  35510728
• Pubmed Central ID:
  PMC9357116
• Document Type:
  Journal Article
• Funding:
  75N99021D00009/OF/ORFDO NIH HHSUnited States/ ; HHSN261201000037C/CA/NCI NIH HHSUnited States/ ; N01PC35143/CA/NCI NIH HHSUnited States/ ; P30 ES005605/ES/NIEHS NIH HHSUnited States/ ; NU58DP006320/CC/CDC HHSUnited States/ ; U58 DP003875/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201000036C/CA/NCI NIH HHSUnited States/ ; 75N96021D00009/ES/NIEHS NIH HHSUnited States/ ; U58 DP000807/DP/NCCDPHP CDC HHSUnited States/ ; N01PC35142/CA/NCI NIH HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; U58 DP000848/DP/NCCDPHP CDC HHSUnited States/ ; ZIA CP010150/ImNIH/Intramural NIH HHSUnited States/ ; U58 DP003883/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201000035C/CA/NCI NIH HHSUnited States/ ; N01PC35137/CA/NCI NIH HHSUnited States/ ; HHSN261201800016C/CA/NCI NIH HHSUnited States/ ; HHSN261201800016I/CA/NCI NIH HHSUnited States/ ; U58 DP003933/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; U58 DP003921/DP/NCCDPHP CDC HHSUnited States/ ; N01PC35139/CA/NCI NIH HHSUnited States/ ; HHSN261201800002C/CA/NCI NIH HHSUnited States/ ; HHSN261201800006I/CA/NCI NIH HHSUnited States/ ; U58 DP000824/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201800002B/CA/NCI NIH HHSUnited States/ ; 75N92021D00009/HL/NHLBI NIH HHSUnited States/ ; 75N90021D00009/HL/NHLBI NIH HHSUnited States/
• Volume:
  22
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:cc1cc89292fc279aff5159e9cbc0ac58973fe8452488e9b9a2f3f72a776e75d6c82245d872a3be988545486c5b78c276883b306eb793426831fc3d5e5d7b1eff
• Download URL:
  https://stacks.cdc.gov/view/cdc/120103/cdc_120103_DS1.pdf
• File Type:
  [PDF - 229.20 KB ]