Changes in cancer incidence and outcomes among kidney transplant recipients in the United States over a thirty-year period.

Blosser, Christopher D; Haber, Gregory; Engels, Eric A

doi:10.1016/j.kint.2020.10.018

Advanced Search

Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

Advanced Search
Custom Query

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Clear All

Query Builder

Query box

Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Changes in cancer incidence and outcomes among kidney transplant recipients in the United States over a thirty-year period.

6 2021
By Blosser, Christopher D ; Haber, Gregory ; Engels, Eric A
http://dx.doi.org/10.1016/j.kint.2020.10.018
Source: Kidney Int. 99(6):1430-1438

[PDF-469.15 KB]

English

Details Supporting Files You May Also Like

Details:

Alternative Title:

Kidney Int
Personal Author:

Blosser, Christopher D ; Haber, Gregory ; Engels, Eric A

Blosser, Christopher D ; Haber, Gregory ; Engels, Eric A Less -
Description:

Recipients of kidney transplants have elevated cancer risk compared with the general population. Improvements over time in transplant care and cancer treatment may have affected incidence and outcomes of cancer among recipients of kidney transplant. To evaluate this, we used linked United States transplant and cancer registry data to study 101,014 adult recipients of kidney transplants over three decades (1987-1996, 1997-2006, 2007-2016). Poisson regression was used to assess trends in incidence for cancer overall and seven common cancers. Associations of cancer with risk of death-censored graft failure (DCGF) and death with functioning graft (DWFG) were evaluated with Cox regression. We also estimated absolute risks of DCGF and graft failure following cancer for recipients transplanted in 2007-2016. There was no significant change in the incidence of cancer overall or for six common cancers in recipients across the 1987-2016 period. Only the incidence of prostate cancer significantly decreased across this period after multivariate adjustment. Among recipients of kidney transplants with non-Hodgkin lymphoma, there were significant declines over time in elevated risks for DCGF and DWFG but no significant changes for other combined cancers. For recipients transplanted in the most recent period (2007-2016), risks following cancer diagnosis remained high, with 38% experiencing DWFG and 14% graft failure within four years of diagnosis. Absolute risk of DWFG was especially high following lung cancer (78%), non-Hodgkin lymphoma (38%), melanoma (35%), and colorectal cancer (49%). Thus, across a 30-year period in the United States, there was no overall change in cancer incidence among recipients of kidney transplants. Despite improvements for non-Hodgkin lymphoma, cancer remains a major cause of morbidity and mortality.
Subjects:

[+]

Adult Graft Rejection Graft Survival Humans Incidence Kidney Transplantation Male Neoplasms Registries Transplant Recipients United States
Keywords:

[+]

Buprenorphine Cancer Graft Failure Kidney Transplant Methadone Mortality Naltrexone Treatment
Source:

Kidney Int. 99(6):1430-1438
Pubmed ID:

33159960
Pubmed Central ID:

PMC8096865
Document Type:

Journal Article
Funding:

U58 DP003931/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201000037C/CA/NCI NIH HHSUnited States/ ; N01PC35143/CA/NCI NIH HHSUnited States/ ; Z01 CP010150/ImNIH/Intramural NIH HHSUnited States/ ; U58 DP003875/DP/NCCDPHP CDC HHSUnited States/ ; ... More +

U58 DP003931/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201000037C/CA/NCI NIH HHSUnited States/ ; N01PC35143/CA/NCI NIH HHSUnited States/ ; Z01 CP010150/ImNIH/Intramural NIH HHSUnited States/ ; U58 DP003875/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201000036C/CA/NCI NIH HHSUnited States/ ; N01PC35137/CA/NCI NIH HHSUnited States/ ; HHSN261201300071C/CA/NCI NIH HHSUnited States/ ; U58 DP003920/DP/NCCDPHP CDC HHSUnited States/ ; U58 DP000807/DP/NCCDPHP CDC HHSUnited States/ ; N01PC35142/CA/NCI NIH HHSUnited States/ ; U58 DP003933/DP/NCCDPHP CDC HHSUnited States/ ; U58 DP000848/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201800002B/CA/NCI NIH HHSUnited States/ ; U58 DP003883/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201000035C/CA/NCI NIH HHSUnited States/ ; HHSN261201300021C/CA/NCI NIH HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; U58 DP003921/DP/NCCDPHP CDC HHSUnited States/ ; N01PC35139/CA/NCI NIH HHSUnited States/ ; HHSN261201800002C/CA/NCI NIH HHSUnited States/ ; HHSN261201300011C/CA/NCI NIH HHSUnited States/ ; U58 DP000824/DP/NCCDPHP CDC HHSUnited States/ Less -
Volume:

99
Issue:

6
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha-512:6e15ea67c32c7f9df93dee553a9bd304c1dca172ba23e78a52a33d334a3e9323623ee4548033779896a6bbfed423dad17ffa7ea9682ac165fbd3013f230160db
Download URL:

https://stacks.cdc.gov/view/cdc/105961/cdc_105961_DS1.pdf
File Type:

	nihms-1697138-f0001.jpg	jpeg
	nihms-1697138-f0002.gif	gif
	nihms-1697138-f0002.jpg	jpeg
	nihms-1697138.nxml	xml

More +