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Rapid In Vivo Detection of Rat Spinal Cord Injury with Double Diffusion Encoded Magnetic Resonance Spectroscopy
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4 2017
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Source: Magn Reson Med. 77(4):1639-1649
[PDF-1.97 MB]
Details:
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Alternative Title:Magn Reson Med
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Description:Purpose
Diffusion weighted imaging is a common experimental tool for evaluating spinal cord injury (SCI), yet suffers from complications decreasing its clinical effectiveness. The most commonly used technique, Diffusion Tensor Imaging (DTI), is often confounded by effects of edema accompanying acute SCI, limiting its sensitivity to the important functional status marker of axonal integrity. The purpose of this study is to introduce a novel diffusion acquisition method with the goal of overcoming these limitations.
Methods
A Double Diffusion Encoding (DDE) pulse sequence was implemented with a diffusion-weighted filter orthogonal to the spinal cord for suppressing non-neural signals prior to diffusion weighting parallel to the cord. A Point-RESolved Spectroscopy readout (DDE-PRESS) was used for improved sensitivity and compared with DTI in a rat model of SCI with varying injury severities.
Results
The DDE-PRESS parameter, restricted fraction, showed a strong relationship with injury severity (p<0.001, R2=0.67). Whereas whole-cord averaged DTI parameter values exhibited only minor injury relationships, a weighted ROI-based DTI analysis improved sensitivity to injury (p<0.001, R2=0.66).
Conclusion
In a rat model of SCI, DDE-PRESS demonstrated high sensitivity to injury with substantial decreases in acquisition time and data processing. This method shows promise for application in rapid evaluation of SCI severity.
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Pubmed ID:27080726
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Pubmed Central ID:PMC5285487
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