Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2807.212353
Personal Author:
Shea, Joseph ; Smith, Carol ; Halse, Tanya A. ; Kohlerschmidt, Donna ; Rourke, Amy K. ; ... More +
Shea, Joseph ; Smith, Carol ; Halse, Tanya A. ; Kohlerschmidt, Donna ; Rourke, Amy K. ; Musser, Kimberlee A. ; Escuyer, Vincent ; Lapierre, Pascal Less -
Description:
We report the unusual genotypic characterization of a bacterium isolated from a clinical sample of a patient who grew up in Bangladesh and lives in the United States. Using whole-genome sequencing, we identified the bacterium as a member of the Mycobacterium tuberculosis complex (MTBC). Phylogenetic placement of this strain suggests a new MTBC genotype. Even though it had the same spoligotype as M. caprae strains, single-nucleotide polymorphism-based phylogenetic analysis placed the isolate as a sister lineage distinct from M. caprae, most closely related to 5 previously sequenced genomes isolated from primates and elephants in Asia. We propose a new animal-associated lineage, La4, within MTBC.
Subject:
[+]
Animals
Genotype
Humans
Phylogeny
Whole Genome Sequencing

Source:
Emerg Infect Dis. 2022; 28(7):1431-1436
Pubmed ID:
35731170
Pubmed Central ID:
PMC9239888
Document Type:
Journal Article
Place as Subject:
Bangladesh ; United States
Bangladesh ; United States Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:866f02abe4aba48f4c618b414258c042fa5933ea0e837a80500df122c0eaca99
File Type:

Supporting Files

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  	21-2353-Techapp-s1.xlsx	xlsx
  	21-2353.nxml	xml

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