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Novel Mycobacterium tuberculosis Complex Genotype Related to M. caprae
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7 2022
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Source: Emerg Infect Dis. 2022; 28(7):1431-1436
[PDF-1.42 MB]
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Alternative Title:Emerg Infect Dis
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Description:We report the unusual genotypic characterization of a bacterium isolated from a clinical sample of a patient who grew up in Bangladesh and lives in the United States. Using whole-genome sequencing, we identified the bacterium as a member of the Mycobacterium tuberculosis complex (MTBC). Phylogenetic placement of this strain suggests a new MTBC genotype. Even though it had the same spoligotype as M. caprae strains, single-nucleotide polymorphism-based phylogenetic analysis placed the isolate as a sister lineage distinct from M. caprae, most closely related to 5 previously sequenced genomes isolated from primates and elephants in Asia. We propose a new animal-associated lineage, La4, within MTBC.
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Pubmed ID:35731170
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Pubmed Central ID:PMC9239888
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Volume:28
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Issue:7
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