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Bacteriophage-loaded poly(lactic-co-glycolic acid) microparticles mitigates Staphylococcus aureus infection and co-cultures of Staphylococcus aureus and Pseudomonas aeruginosa
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5 2022
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Source: Adv Healthc Mater. 11(10):e2102539
[PDF-1.38 MB]
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Alternative Title:Adv Healthc Mater
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Description:Lung infections caused by Gram-positive Staphylococcus aureus (S. aureus) and coinfections caused by S. aureus and Gram-negative Pseudomonas aeruginosa (P. aeruginosa) are challenging to treat, especially with the rise in the number of antibiotic-resistant strains of these pathogens. Bacteriophage (phage) are bacteria-specific viruses that can infect and lyse bacteria, providing a potentially effective therapy for bacterial infections. However, the development of bacteriophage therapy is impeded by limited suitable biomaterials that can facilitate effective delivery of phage to the lung. Here, the ability of porous microparticles engineered from poly(lactic-co-glycolic acid) (PLGA), a biodegradable polyester, to effectively deliver phage to the lung, is demonstrated. The phage-loaded microparticles (phage-MPs) display potent antimicrobial efficacy against various strains of S. aureus in vitro and in vivo, and arrest the growth of a clinical isolate of S. aureus in the presence of sputum supernatant obtained from cystic fibrosis patients. Moreover, phage-MPs efficiently mitigate in vitro cocultures of S. aureus and P. aeruginosa and display excellent cytocompatibility with human lung epithelial cells. Therefore, phage-MPs represents a promising therapy to treat bacterial lung infection.
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Pubmed ID:34957709
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Pubmed Central ID:PMC9117426
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Funding:Parker H. Petit Institute for Bioengineering and Bioscience at the Georgia Institute of Technology/ ; Airways Disease Research, Children's Healthcare of Atlanta and Emory University/ ; Cystic Fibrosis Biospecimen Repository at the Children's Healthcare of Atlanta and Emory University CF Discovery Core/ ; NIH R01 AR062920/NH/NIH HHSUnited States/ ; R01 AR062920/AR/NIAMS NIH HHSUnited States/ ; ... More +
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Volume:11
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Issue:10
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