Epidemiology of Childhood-Onset Systemic Lupus Erythematosus: A Population-Based Study

Details

• Alternative Title:
  Arthritis Care Res (Hoboken)
• Personal Author:
  Valenzuela-Almada, Maria O. ; Hocaoglu, Mehmet ; Dabit, Jesse Y. ; Osei-Onomah, Shirley-Ann ; Basiaga, Matthew L ; Orandi, Amir B. ; Giblon, Rachel E. ; Barbour, Kamil E. ; Crowson, Cynthia S. ; Duarte-García, Alí
• Description:
  Objective: ; To characterize the incidence and prevalence of childhood onset systemic lupus erythematosus (cSLE), and to estimate the proportion of patients who are diagnosed with SLE during childhood. ; Methods: ; A cohort of patients with incident cSLE in 1976 to 2018 from a US 8-county region were identified based on comprehensive medical record review. All cases met the European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) or ACR 97 criteria at or before age 18. Incidence rates were estimated using Poisson methods. We estimated the cSLE point prevalence for 1/1/2015. Results were sex/age-adjusted to the US 2000 population. Among all the SLE patients living in the 8-county region in 1/1/2015, the proportion of patients diagnosed at ≤18 years was estimated. ; Results: ; A total of 13 children were diagnosed with cSLE during the study period (EULAR/ACR definition, mean age at diagnosis 15.1 years; 85% female, 69% White). cSLE overall adjusted incidence rate was 0.7 (95% CI, 0.2-1.1) per 100,000 children. Incidence rate in girls was 1.2 (95% CI, 0.5-1.9) per 100,000, while in boys it was 0.2 (95% CI, 0.0-0.5) per 100,000. Adjusted prevalence of cSLE was 1.1 (95% CI,0.0-3.1) per 100,000 children. The proportion of patients with SLE diagnosed as children was 9% (95% CI, 6-13%). ; Conclusions: ; In this population-based study, both the incidence and prevalence rates of cSLE were ~ 1 per 100,000 children. One in ten adults with SLE were diagnosed in childhood. More studies are needed to further characterize the epidemiology of cSLE in minorities.
• Subjects:
  • Adolescent
  • Adult
  • Child
  • Female
  • Humans
  • Lupus Erythematosus, Systemic
  • Male
  • Rheumatology
  • White
• Source:
  Arthritis Care Res (Hoboken). 74(5):728-732
• Pubmed ID:
  34825516
• Pubmed Central ID:
  PMC9038612
• Document Type:
  Text
• Funding:
  UL1 TR002377/TR/NCATS NIH HHSUnited States/ ; R01 AG034676/AG/NIA NIH HHSUnited States/ ; U01 DP006491/DP/NCCDPHP CDC HHSUnited States/ ; R33 AG058738/AG/NIA NIH HHSUnited States/
• Genre:
  Journal Article
• Volume:
  74
• Issue:
  5
• Download URL:
  https://stacks.cdc.gov/view/cdc/116726/cdc_116726_DS1.pdf
• File Type:
  [PDF - 313.83 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:4cd516f84379ca67d98999db8ae29ddf060fd81a57d72c08628d8b80272d403f6b9648d9b285db7e9021a93f2c31570f1541658140cff1b36b7cae5b645ff6de