Influenza polymerase inhibitor resistance: Assessment of the current state of the art - A report of the isirv Antiviral group

Details

• Alternative Title:
  Antiviral Res
• Personal Author:
  Ison, Michael G. ; Hayden, Frederick G. ; Hay, Alan J. ; Gubareva, Larisa V. ; Govorkova, Elena A. ; Takashita, Emi ; McKimm-Breschkin, Jennifer L.
• Description:
  It is more than 20 years since the neuraminidase inhibitors, oseltamivir and zanamivir were approved for the treatment and prevention of influenza. Guidelines for global surveillance and methods for evaluating resistance were established initially by the Neuraminidase Inhibitor Susceptibility Network (NISN), which merged 10 years ago with the International Society for influenza and other Respiratory Virus Diseases (isirv) to become the isirv-Antiviral Group (isirv-AVG). With the ongoing development of new influenza polymerase inhibitors and recent approval of baloxavir marboxil, the isirv-AVG held a closed meeting in August 2019 to discuss the impact of resistance to these inhibitors. Following this meeting and review of the current literature, this article is intended to summarize current knowledge regarding the clinical impact of resistance to polymerase inhibitors and approaches for surveillance and methods for laboratory evaluation of resistance, both in vitro and in animal models. We highlight limitations and gaps in current knowledge and suggest some strategies for addressing these gaps, including the need for additional clinical studies of influenza antiviral drug combinations. Lessons learned from influenza resistance monitoring may also be helpful for establishing future drug susceptibility surveillance and testing for SARS-CoV-2.
• Subjects:
  Animals Antiviral Agents Dibenzothiepins Drug Resistance, Viral Enzyme Inhibitors Humans Influenza, Human Knowledge Morpholines Neuraminidase Oseltamivir Pyridones SARS-CoV-2 Triazines Virus Replication Zanamivir

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• Keywords:
  Antiviral Baloxavir Buprenorphine Drug Resistance Fitness Influenza Virus Methadone Mortality Naltrexone Polymerase Inhibitor Treatment

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• Source:
  Antiviral Res. 194:105158
• Pubmed ID:
  34363859
• Pubmed Central ID:
  PMC9012257
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  194
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:0a1b8009f38d959a810127ce70a10f2ec00617da05d9f97c82cda96df2558ce65a52c978f211823efaf448e677f1a7c060eabd27da207cb618bbb8bd395f3c67
• Download URL:
  https://stacks.cdc.gov/view/cdc/116479/cdc_116479_DS1.pdf
• File Type:
  [PDF - 439.71 KB ]