In Vitro Confirmation of Artemisinin Resistance in Plasmodium falciparum from Patient Isolates, Southern Rwanda, 2019

van Loon, Welmoed; Oliveira, Rafael; Bergmann, Clara; Habarugira, Felix; Ndoli, Jules; Sendegeya, Augustin; Bayingana, Claude; Mockenhaupt, Frank P.

doi:10.3201/eid2804.212269

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In Vitro Confirmation of Artemisinin Resistance in Plasmodium falciparum from Patient Isolates, Southern Rwanda, 2019

4 2022
By van Loon, Welmoed ; Oliveira, Rafael ; Bergmann, Clara ; ...
http://dx.doi.org/10.3201/eid2804.212269
Source: Emerg Infect Dis. 2022; 28(4):852-855

[PDF-1.03 MB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

van Loon, Welmoed ; Oliveira, Rafael ; Bergmann, Clara ; Habarugira, Felix ; Ndoli, Jules ; ... More +

van Loon, Welmoed ; Oliveira, Rafael ; Bergmann, Clara ; Habarugira, Felix ; Ndoli, Jules ; Sendegeya, Augustin ; Bayingana, Claude ; Mockenhaupt, Frank P. Less -
Description:

Artemisinin resistance in Plasmodium falciparum is conferred by mutations in the kelch 13 (K13) gene. In Rwanda, K13 mutations have increased over the past decade, including mutations associated with delayed parasite clearance. We document artemisinin resistance in P. falciparum patient isolates from Rwanda carrying K13 R561H, A675V, and C469F mutations.
Subjects:

[+]

Antimalarials Artemisinins Humans Protozoan Proteins
Source:

Emerg Infect Dis. 2022; 28(4):852-855
Pubmed ID:

35318931
Pubmed Central ID:

PMC8962885
Document Type:

Journal Article
Place as Subject:

Rwanda
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:856e33e10b992c43e03cce924d64a0d5c0db561f502d119cb2236bf0c8a807a0
Download URL:

https://stacks.cdc.gov/view/cdc/116341/cdc_116341_DS1.pdf
File Type:

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