In Vitro Confirmation of Artemisinin Resistance in Plasmodium falciparum from Patient Isolates, Southern Rwanda, 2019

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  van Loon, Welmoed ; Oliveira, Rafael ; Bergmann, Clara ; Habarugira, Felix ; Ndoli, Jules ; Sendegeya, Augustin ; Bayingana, Claude ; Mockenhaupt, Frank P.
• Description:
  Artemisinin resistance in Plasmodium falciparum is conferred by mutations in the kelch 13 (K13) gene. In Rwanda, K13 mutations have increased over the past decade, including mutations associated with delayed parasite clearance. We document artemisinin resistance in P. falciparum patient isolates from Rwanda carrying K13 R561H, A675V, and C469F mutations.
• Subjects:
  Antimalarials Artemisinins Humans Protozoan Proteins
• Source:
  Emerg Infect Dis. 2022; 28(4):852-855
• Pubmed ID:
  35318931
• Pubmed Central ID:
  PMC8962885
• Document Type:
  Journal Article
• Place as Subject:
  Rwanda
• Volume:
  28
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:856e33e10b992c43e03cce924d64a0d5c0db561f502d119cb2236bf0c8a807a0
• Download URL:
  https://stacks.cdc.gov/view/cdc/116341/cdc_116341_DS1.pdf
• File Type:
  [PDF - 1.03 MB ]