Details:

Alternative Title:
J Viral Hepat
Publisher's site:
http://dx.doi.org/10.1111/jvh.12890
Personal Author:
Choi, Y. H. ; Zhang, X. ; Tran, C. ; Skinner, B.
Choi, Y. H. ; Zhang, X. ; Tran, C. ; Skinner, B. Less -
Description:
Hepatitis E virus (HEV) genotype (gt) 3 infection is food-borne causing sporadic infections in older individuals and gt1 infection is waterborne, often causing epidemics affecting primarily young adults. Although HEV infection causes self-limited disease, gt3 induces chronic infection in immunocompromised individuals. Hepatic host gene expression against gt3 infection remains unknown. Host gene expression profiles for HEV gt1 (n = 3) and gt3 (n = 7) infections were analysed in the livers of experimentally infected rhesus macaques. HEV RNA was detected from 2 to 24 days after inoculation (DAI) in stool and serum, elevated alanine aminotransferase (ALT) activity was detected from 7 to 31 DAI, and anti-HEV antibody became detectable between 12 and 42 DAI. All 10 animals cleared the infection between 34 and 68 DAI. We found that 24%, 48% and 41% of hepatic immune response genes against gt3 infection were upregulated during the early, peak and decline phases of HEV RNA replication. For gt1 infection, 25% of hepatic immune response-related genes were downregulated during early viremia, but 6%, 34% and 37% of genes were upregulated at the early, peak and during decline of HEV RNA replication, respectively. Our study demonstrated distinct differences in the expression profiles of host immune response-related genes of HEV gt3 and gt1 infections in experimentally infected rhesus macaques.
Subject:
[+]
Acute Infection Alanine Transaminase Animals Article Disease Models, Animal Feces Gene Expression Profiling Genotype Genotype 1 Genotype 3 Hepatitis Antibodies Hepatitis E Hepatitis E Virus Host Immune Response-related Genes Immunologic Factors Liver Macaca Mulatta Rhesus Macaques RNA, Viral Serum Time Factors Hepatitis E Virus
Source:
J Viral Hepat. 25(8):986-995
Pubmed ID:
29532615
Pubmed Central ID:
PMC8996335
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:36cce64bd8c2074ab79cff7cbde79af0976d966444923e62fb0d0209149b90a8
Download URL:
https://stacks.cdc.gov/view/cdc/116201/cdc_116201_DS1.pdf
File Type:

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