Cancer Specific Survival in Patients with Sickle Cell Disease

Details

• Alternative Title:
  Br J Haematol
• Personal Author:
  Brunson, Ann ; Keegan, Theresa H.M. ; Mahajan, Anjlee ; Paulukonis, Susan ; Wun, Ted
• Description:
  Sickle cell disease (SCD) patients have a higher incidence of certain cancers, but no studies have determined the impact of cancer on survival among SCD patients. SCD patients (n = 6423), identified from state-wide hospitalisation data, were linked to the California Cancer Registry (1988-2014). Multivariable Cox proportional hazards regression was used to examine survival. Among SCD patients, a cancer diagnosis was associated with a 3-fold increased hazard of death. Compared to matched cancer patients without SCD, SCD was associated with worse overall survival, but not cancer-specific survival, suggesting that SCD cancer patients should be treated with similar therapeutic intent.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Age Distribution Anemia, Sickle Cell Article California Comorbidity Disease Susceptibility Ethnicity Female Follow-Up Studies Humans Incidence Male Middle Aged Neoplasms Proportional Hazards Models Risk Sex Distribution Young Adult

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• Source:
  Br J Haematol. 185(1):128-132
• Pubmed ID:
  30467842
• Pubmed Central ID:
  PMC8966490
• Document Type:
  Journal Article
• Funding:
  R21 HL129033/HL/NHLBI NIH HHSUnited States/ ; HHSN261201000035C/CA/NCI NIH HHSUnited States/ ; U58 DP003862/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; UL1 TR001860/TR/NCATS NIH HHSUnited States/ ; HHSN261201000140C/CA/NCI NIH HHSUnited States/
• Volume:
  185
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f708b0aef900458a4134d12054ae25fec09facaaae25957b6ac9866721af625e
• Download URL:
  https://stacks.cdc.gov/view/cdc/115860/cdc_115860_DS1.pdf
• File Type:
  [PDF - 182.44 KB ]