Details:

Alternative Title:
Birth Defects Res
Publisher's site:
http://dx.doi.org/10.1002/bdr2.1116
Personal Author:
Hoang, Thanh T. ; Agopian, A.J. ; Mitchell, Laura E.
Hoang, Thanh T. ; Agopian, A.J. ; Mitchell, Laura E. Less -
Description:
Background:

Several studies have assessed potential associations between use of weight loss products in the periconceptional period and neural tube defects (NTDs). However, the individual studies are inconclusive and there has not been a systematic review of this literature.

Methods:

We conducted a systematic search, using Ovid MEDLINE and PubMed, to identify studies that evaluated the association between products used for weight loss and the risk of NTDs. Because many studies of birth defects only evaluate a composite birth defect outcome, we evaluated studies that defined the outcome as “any major birth defect” or as NTDs. We abstracted data on study design, exposure definition, outcome definition, covariates and effect size estimates from each article that met our inclusion criteria. For studies that evaluated a composite birth defect outcome, we also abstracted the number of NTD cases included in the composite outcome. We used a modified version of the Newcastle-Ottawa Scale to assess the quality of each article.

Results:

We screened 865 citations and identified nine articles that met our inclusion criteria. The majority of studies reported positive associations between maternal use of weight loss products and birth defects (overall and NTDs). However, there were few significant associations and there was considerable heterogeneity in the specific exposures assessed across the nine studies.

Conclusion:

Our systematic review of weight loss products and NTDs indicates that the literature on this topic is sparse. Because several studies reported modest, positive associations between risk and use of weight loss products, additional studies are warranted.


Subject:
[+]
Anti-Obesity Agents
Article
Birth Defects
Dieting
Female
Humans
Neural Tube Defects
Pregnancy
Prenatal Exposure Delayed Effects
Risk Factors
Spina Bifida
Weight Loss
Neural Tube Defects
Pregnancy
Weight Loss

Source:
Birth Defects Res. 110(1):48-55
Pubmed ID:
29024488
Pubmed Central ID:
PMC8919237
Document Type:
Journal Article
Funding:
U01 DD001179/DD/NCBDD CDC HHSUnited States/ ; U01DD001179/ACL/ACL HHSUnited States/
U01 DD001179/DD/NCBDD CDC HHSUnited States/ ; U01DD001179/ACL/ACL HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:0fcad482cca36c63e41a538047ebb82ee79de01516b99455f29b591c728e1095
File Type:

Supporting Files

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  	NIHMS1783027-supplement-supinfo.docx	docx

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