Treatment Outcomes of Childhood Tuberculous Meningitis in a Real-World Retrospective Cohort, Bandung, Indonesia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Nataprawira, Heda M. ; Gafar, Fajri ; Risan, Nelly A. ; Wulandari, Diah A. ; Sudarwati, Sri ; Marais, Ben J. ; Stevens, Jasper ; Alffenaar, Jan-Willem C. ; Ruslami, Rovina
• Description:
  We retrospectively evaluated clinical features and outcomes in children treated for tuberculous meningitis (TBM) at Hasan Sadikin Hospital, Bandung, Indonesia, during 2011-2020. Among 283 patients, 153 (54.1%) were <5 years of age, and 226 (79.9%) had stage II or III TBM. Predictors of in-hospital death (n = 44 [15.5%]) were stage III TBM, hydrocephalus, male sex, low-income parents, seizures at admission, and lack of bacillus Calmette-Guérin vaccination. Predictors of postdischarge death (n = 18 [6.4%]) were hydrocephalus, tuberculoma, and lack of bacillus Calmette-Guérin vaccination. At treatment completion, 91 (32.1%) patients were documented to have survived, of whom 33 (36.3%) had severe neurologic sequelae and 118 (41.7%) had unknown outcomes. Predictors of severe neurologic sequelae were baseline temperature >38°C, stage III TBM, and baseline motor deficit. Despite treatment, childhood TBM in Indonesia causes substantial neurologic sequelae and death, highlighting the importance of improved early diagnosis, better tuberculosis prevention, and optimized TBM management strategies.
• Subjects:
  Bacteria Children Indonesia Morbidity Mortality Neurologic Sequelae Research Treatment Outcome Treatment Outcomes Of Childhood Tuberculous Meningitis In A Real-World Retrospective Cohort, Bandung, Indonesia Tuberculosis Tuberculosis And Other Mycobacteria Tuberculous Meningitis

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• Source:
  Emerg Infect Dis. 2022; 28(3):660-671
• Pubmed ID:
  35202524
• Pubmed Central ID:
  PMC8888221
• Document Type:
  Journal Article
• Volume:
  28
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:f1fb37f535e54fe56edf0b85dd75eae23dfd41c8ee85e2ad1c6318dc28264d02
• Download URL:
  https://stacks.cdc.gov/view/cdc/115230/cdc_115230_DS1.pdf
• File Type:
  [PDF - 1.17 MB ]