Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2803.211499
Personal Author:
Rogier, Eric ; McCaffery, Jessica N. ; Nace, Doug ; Svigel, Samaly Souza ; Assefa, Ashenafi ; ... More +
Rogier, Eric ; McCaffery, Jessica N. ; Nace, Doug ; Svigel, Samaly Souza ; Assefa, Ashenafi ; Hwang, Jimee ; Kariuki, Simon ; Samuels, Aaron M. ; Westercamp, Nelli ; Ratsimbasoa, Arsène ; Randrianarivelojosia, Milijaona ; Uwimana, Aline ; Udhayakumar, Venkatachalam ; Halsey, Eric S. Less -
Description:
Histidine-rich protein 2 (HRP2)-based rapid diagnostic tests detect Plasmodium falciparum malaria and are used throughout sub-Saharan Africa. However, deletions in the pfhrp2 and related pfhrp3 (pfhrp2/3) genes threaten use of these tests. Therapeutic efficacy studies (TESs) enroll persons with symptomatic P. falciparum infection. We screened TES samples collected during 2016-2018 in Ethiopia, Kenya, Rwanda, and Madagascar for HRP2/3, pan-Plasmodium lactate dehydrogenase, and pan-Plasmodium aldolase antigen levels and selected samples with low levels of HRP2/3 for pfhrp2/3 genotyping. We observed deletion of pfhrp3 in samples from all countries except Kenya. Single-gene deletions in pfhrp2 were observed in 1.4% (95% CI 0.2%-4.8%) of Ethiopia samples and in 0.6% (95% CI 0.2%-1.6%) of Madagascar samples, and dual pfhrp2/3 deletions were noted in 2.0% (95% CI 0.4%-5.9%) of Ethiopia samples. Although this study was not powered for precise prevalence estimates, evaluating TES samples revealed a low prevalence of pfhrp2/3 deletions in most sites.
Subject:
[+]
Antigens, Protozoan
Diagnostic Tests, Routine
Gene Deletion
Humans
Malaria
Malaria, Falciparum
Plasmodium Falciparum
Protozoan Proteins

Source:
Emerg Infect Dis. 2022; 28(3):608-616
Pubmed ID:
35201739
Pubmed Central ID:
PMC8888236
Document Type:
Journal Article
Place as Subject:
Ethiopia ; Kenya ; Madagascar ; Rwanda
Ethiopia ; Kenya ; Madagascar ; Rwanda Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:52db4ed14a44babffba816ad8ff51d3fc9bf78120efa454b60b346a0419850a8
File Type:

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