Plasmodium falciparum Histidine-Rich Protein 2 and 3 Gene Deletions in Strains from Nigeria, Sudan, and South Sudan

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Prosser, Christiane ; Gresty, Karryn ; Ellis, John ; Meyer, Wieland ; Anderson, Karen ; Lee, Rogan ; Cheng, Qin
• Description:
  Deletion of histidine-rich protein genes pfhrp2/3 in Plasmodium falciparum causes infections to go undetected by HRP2-based malaria rapid diagnostic tests. We analyzed P. falciparum malaria cases imported to Australia (n = 210, collected 2010-2018) for their pfhrp2/3 status. We detected gene deletions in patients from 12 of 25 countries. We found >10% pfhrp2-deletion levels in those from Nigeria (13.3%, n = 30), Sudan (11.2%, n = 39), and South Sudan (17.7%, n = 17) and low levels of pfhrp3 deletion from Sudan (3.6%) and South Sudan (5.9%). No parasites with pfhrp2/3 double deletions were detected. Microsatellite typing of parasites from Nigeria, Sudan, and South Sudan revealed low relatedness among gene-deleted parasites, indicating independent emergences. The gene deletion proportions signify a risk of false-negative HRP2-RDT results. This study's findings warrant surveillance to determine whether the prevalence of gene-deleted parasites justifies switching malaria rapid diagnostic tests in Nigeria, Sudan, and South Sudan.
• Subjects:
  Antigens, Protozoan Diagnostic Tests, Routine Gene Deletion Histidine Humans Malaria, Falciparum Plasmodium Falciparum Protozoan Proteins
• Source:
  Emerg Infect Dis. 27(2):471-479
• Pubmed ID:
  33496220
• Pubmed Central ID:
  PMC7853540
• Document Type:
  Journal Article
• Place as Subject:
  Australia ; Nigeria ; Sudan ; South Sudan
• Volume:
  27
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:21ec0df396dcd048c40d2499aef3100b6364be653b34d2cf9f1125a554bef608
• Download URL:
  https://stacks.cdc.gov/view/cdc/102435/cdc_102435_DS1.pdf
• File Type:
  [PDF - 1.27 MB ]