Case–Control Study of Clostridium innocuum Infection, Taiwan

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Chen, Yi-Ching ; Kuo, Yi-Chun ; Chen, Mi-Chi ; Zhang, Young-Da ; Chen, Chyi-Liang ; Le, Puo-Hsien ; Chiu, Cheng-Hsun
• Description:
  Vancomycin-resistant Clostridium innocuum was recently identified as an etiologic agent for antibiotic-associated diarrhea in humans. We conducted a case-control study involving 152 C. innocuum-infected patients during 2014-2019 in Taiwan, using 304 cases of Clostridioides difficile infection (CDI) matched by diagnosis year, age (+2 years), and sex as controls. The baseline characteristics were similar between the 2 groups. C. innocuum-infected patients experienced more extraintestinal clostridial infection and gastrointestinal tract-related complications than did patients with CDI. The 30-day mortality rate among C. innocuum-infected patients was 14.5%, and the overall rate was 23.0%. Chronic kidney disease, solid tumor, intensive care unit admission, and shock status were 4 independent risk factors for death. C. innocuum identified from clinical specimens should be recognized as a pathogen requiring treatment, and because of its intrinsic vancomycin resistance, precise identification is necessary to guide appropriate and timely antimicrobial therapy.
• Subjects:
  Antimicrobial Resistance Bacteria Case–Control Study Of Clostridium Innocuum Infection, Taiwan Clostridioides Difficile Clostridium Innocuum Enteric Infections Extraintestinal Clostridial Infection Research Taiwan Vancomycin Resistance
• Source:
  Emerg Infect Dis. 2022; 28(3):599-607
• Pubmed ID:
  35195517
• Pubmed Central ID:
  PMC8888209
• Document Type:
  Journal Article
• Volume:
  28
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:599aa00eed2248a8379c29bada9d9627123dfbf300e684e95c004b0fb2f89e68
• Download URL:
  https://stacks.cdc.gov/view/cdc/115195/cdc_115195_DS1.pdf
• File Type:
  [PDF - 1.25 MB ]