Mitohormesis in hypothalamic POMC neurons mediates regular exercise-induced high-turnover metabolism

Kang, Gil Myoung; Min, Se Hee; Lee, Chan Hee; Kim, Ji Ye; Lim, Hyo Sun; Choi, Min Jeong; Jung, Saet-Byel; Park, Jae Woo; Kim, Seongjun; Park, Chae Beom; Dugu, Hong; Choi, Jong Han; Jang, Won Hee; Park, Se Eun; Cho, Young Min; Kim, Jae Geun; Kim, Kyung-Gon; Choi, Cheol Soo; Kim, Young-Bum; Lee, Changhan; Shong, Minho; Kim, Min-Seon

doi:10.1016/j.cmet.2021.01.003

i

Mitohormesis in hypothalamic POMC neurons mediates regular exercise-induced high-turnover metabolism

Supporting Files

2 02 2021 ; 2-02-
By Kang, Gil Myoung ; Min, Se Hee ; Lee, Chan Hee ; Kim, Ji Ye ; Lim, Hyo Sun ; Choi, Min Jeong ; Jung, Saet-Byel ; Park, Jae Woo ; Kim, Seongjun ; Park, Chae Beom ; Dugu, Hong ; Choi, Jong Han ; Jang, Won Hee ; Park, Se Eun ; Cho, Young Min ; Kim, Jae Geun ; Kim, Kyung-Gon ; Choi, Cheol Soo ; Kim, Young-Bum ; Lee, Changhan ; Shong, Minho ; Kim, Min-Seon
http://dx.doi.org/10.1016/j.cmet.2021.01.003
Available in CDC Stacks on February 02, 2022, 12:00 AM

File Language:

English

Details

Alternative Title:

Cell Metab
Personal Author:

Kang, Gil Myoung ; Min, Se Hee ; Lee, Chan Hee ; Kim, Ji Ye ; Lim, Hyo Sun ; Choi, Min Jeong ; Jung, Saet-Byel ; Park, Jae Woo ; Kim, Seongjun ; Park, Chae Beom ; Dugu, Hong ; Choi, Jong Han ; Jang, Won Hee ; Park, Se Eun ; Cho, Young Min ; Kim, Jae Geun ; Kim, Kyung-Gon ; Choi, Cheol Soo ; Kim, Young-Bum ; Lee, Changhan ; Shong, Minho ; Kim, Min-Seon
Description:

Low-grade mitochondrial stress can promote health and longevity, a phenomenon termed mitohormesis. Here, we demonstrate the opposing metabolic effects of low-level and high-level mitochondrial ribosomal (mitoribosomal) stress in hypothalamic proopiomelanocortin (POMC) neurons. POMC neuron-specific severe mitoribosomal stress due to Crif1 homodeficiency causes obesity in mice. By contrast, mild mitoribosomal stress caused by Crif1 heterodeficiency in POMC neurons leads to high-turnover metabolism and resistance to obesity. These metabolic benefits are mediated by enhanced thermogenesis and mitochondrial unfolded protein responses (UPR|) in distal adipose tissues. In POMC neurons, partial Crif1 deficiency increases the expression of β-endorphin (β-END) and mitochondrial DNA-encoded peptide MOTS-c. Central administration of MOTS-c or β-END recapitulates the adipose phenotype of Crif1 heterodeficient mice, suggesting these factors as potential mediators. Consistently, regular running exercise at moderate intensity stimulates hypothalamic MOTS-c/β-END expression and induces adipose tissue UPR| and thermogenesis. Our findings indicate that POMC neuronal mitohormesis may underlie exercise-induced high-turnover metabolism.
Subjects:
Keywords:
Source:

Cell Metab. 33(2):334-349.e6
Pubmed ID:

33535098
Pubmed Central ID:

PMC7959183
Document Type:

Journal Article
Funding:

H23 IP000855/IP/NCIRD CDC HHSUnited States/ ; R01 AG052558/AG/NIA NIH HHSUnited States/ ; R01 DK123002/DK/NIDDK NIH HHSUnited States/ ; R01 GM136837/GM/NIGMS NIH HHSUnited States/
Volume:

33
Issue:

2
Download URL:

https://stacks.cdc.gov/view/cdc/113970/cdc_113970_DS1.pdf
File Type:

[PDF - 3.93 MB]
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha-512:1f01382cf73d8e9f0dd6f98b1cf941bdda495e9c3046fc9e41b35f209da15fa8d09d494fdbccfeaeefdcc48b583716f57a56c26a3fffdc9b29771fac0d8e356e

File Language:

English

ON THIS PAGE

Details Supporting Files

Was this page helpful?

Found an issue?

Send us an email at:

publishinghd@cdc.gov

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.