Effectiveness of a Third Dose of MRNA Vaccines Against COVID-19–associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variants Predominance — VISION Network, 10 States, August 2021–January 2022

Details

• Personal Author:
  Thompson, Mark G. ; Natarajan, Karthik ; Irving, Stephanie A. ; Rowley, Elizabeth A. ; Griggs, Eric P. ; Gaglani, Manjusha ; Klein, Nicola P. ; Grannis, Shaun J. ; DeSilva, Malini B. ; Stenehjem, Edward ; Reese, Sarah E. ; Dickerson, Monica ; Naleway, Allison L. ; Han, Jungmi ; Konatham, Deepika ; McEvoy, Charlene ; Rao, Suchitra ; Dixon, Brian E. ; Dascomb, Kristin ; Lewis, Ned ; Levy, Matthew E. ; Patel, Palak ; Liao, I-Chia ; Kharbanda, Anupam B. ; Barron, Michelle A. ; Fadel, William F. ; Grisel, Nancy ; Goddard, Kristin ; Yang, Duck-Hye ; Wondimu, Mehiret H. ; Murthy, Kempapura ; Valvi, Nimish R. ; Arndorfer, Julie ; Fireman, Bruce ; Dunne, Margaret M. ; Embi, Peter ; Azziz-Baumgartner, Eduardo ; Zerbo, Ousseny ; Bozio, Catherine H. ; Reynolds, Sue ; Ferdinands, Jill ; Williams, Jeremiah ; Link-Gelles, Ruth ; Schrag, Stephanie J. ; Verani, Jennifer R. ; Ball, Sarah ; Ong, Toan C.
• Corporate Authors:
  CDC COVID-19 Response Team ; Columbia University Dept. of Biomedical Informatics ; New York Presbyterian Hospital ; Center for Health Research (Kaiser-Permanente Medical Care Program Northwest Region) ; Texas A&M University College of Medicine Baylor Scott & White Health ; Kaiser Permanente Vaccine Study Center ; Regenstrief Institute for Health Care‏ ; Center for Biomedical Informatics ; Indiana University Richard M. Fairbanks School of Public Health ; HealthPartners Institute ; Intermountain Healthcare, UT ; Div. of Infectious Diseases and Clinical Epidemiology ; University of Colorado Anschutz Medical Campus Dept. of Medicine ; Indiana University Fairbanks School of Public Health ; Vanderbilt University ; VISION Network
• Description:
  What is already known about this topic? COVID-19 mRNA vaccine effectiveness (VE) in preventing COVID-19 might decline because of waning of vaccine-induced immunity or Variants immune evasion.
  
  What is added by this report? VE was significantly higher among patients who received their second mRNA COVID-19 vaccine dose <180 days before medical encounters compared with those vaccinated ≥180 days earlier. During both Delta- and Omicron-predominant periods, receipt of a third vaccine dose was highly effective at preventing COVID-19–associated emergency department and urgent care encounters (94% and 82%, respectively) and preventing COVID-19–associated hospitalizations (94% and 90%, respectively).
  
  What are the implications for public health practice? All unvaccinated persons should start vaccination as soon as possible. All adults who have received mRNA vaccines during their primary COVID-19 vaccination series should receive a third dose when eligible, and eligible persons should stay up to date with COVID-19 vaccinations.
  
  Suggested citation for this article: Thompson MG, Natarajan K, Irving SA, et al. Effectiveness of a Third Dose of mRNA Vaccines Against COVID-19–Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance — VISION Network, 10 States, August 2021–January 2022. MMWR Morb Mortal Wkly Rep. ePub: 21 January 2022.
  
  mm7104e3.htm?s_cid=mm7104e3_w
  
  mm7104e3-H.pdf
  
  
• Subjects:
  2019-nCoV Vaccine MRNA-1273 Adolescent Adult Aged Ambulatory Care Facilities BNT162 Vaccine CoronaVirus Infections/Prevention & Control COVID-19 Vaccines COVID-19/Prevention & Control Emergency Service, Hospital Hospitalization Immunization, Secondary Middle Aged SARS-CoV-2 Vaccination Young Adult

  More +
• Source:
  MMWR: Morbidity and Mortality Weekly Report 2022; v. 71 Early Release
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  8 pdf pages
• Volume:
  71
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:146dd999673682abe4fd42027b8bfe1fe9584077ce39023bcfa768967a0b71e1bb0a793d3f95ff16c7251d703dbdf36a0f99c521ffb156222acd740badf91707
• Download URL:
  https://stacks.cdc.gov/view/cdc/113718/cdc_113718_DS1.pdf
• File Type:
  [PDF - 417.21 KB ]