Streptococcus pneumoniae Serotypes Associated with Death, South Africa, 2012–2018

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Müller, Annelies ; Kleynhans, Jackie ; de Gouveia, Linda ; Meiring, Susan ; Cohen, Cheryl ; Hathaway, Lucy Jane ; von Gottberg, Anne
• Corporate Authors:
  for GERMS-SA
• Description:
  The Streptococcus pneumoniae polysaccharide capsule plays a role in disease severity. We assessed the association of serotype with case-fatality ratio (CFR) in invasive pneumococcal disease (IPD) and meningitis in South Africa, 2012-2018 (vaccine era), using multivariable logistic regression by manual backward elimination. The most common serotypes causing IPD were 8 and 19A. In patients <15 years of age, serotypes associated with increased CFR in IPD, compared with serotype 8 and controlling for confounding factors, were 11A, 13, 19F, 15A, and 6A. None of these serotypes were associated with increased CFR in meningitis. Among IPD patients >15 years of age, serotype 15B/C was associated with increased CFR. Among meningitis patients of all ages, serotype 1 was associated with increased CFR. PCV13 serotypes 1, 3, 6A, 19A, and 19F should be monitored, and serotypes 8, 12F, 15A, and 15B/C should be considered for inclusion in vaccines to reduce deaths caused by S. pneumoniae.
• Subjects:
  Humans Infant Pneumococcal Infections Pneumococcal Vaccines Serogroup
• Source:
  Emerg Infect Dis. 2022; 28(1):166-179
• Pubmed ID:
  34932448
• Pubmed Central ID:
  PMC8714227
• Document Type:
  Journal Article
• Place as Subject:
  South Africa ; Switzerland
• Volume:
  28
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:c43d852aac1cdd6faf7334ed33bd23fe5ac6d165e31723d4dd8b2c394981442a
• Download URL:
  https://stacks.cdc.gov/view/cdc/113326/cdc_113326_DS1.pdf
• File Type:
  [PDF - 2.64 MB ]