Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2801.210497
Personal Author:
Hsieh, Yu-Chia ; Li, Shiao-Wen ; Chen, Yi-Yin ; Kuo, Ching-Chia ; Chen, Yin-Cheng ; ... More +
Hsieh, Yu-Chia ; Li, Shiao-Wen ; Chen, Yi-Yin ; Kuo, Ching-Chia ; Chen, Yin-Cheng ; Chang, Ian Yi-Feng ; Pan, Yi-Jiun ; Li, Ting-Hsuan ; Chiang, Ruei-Lin ; Huang, Ya-Yu ; Liao, Wei-Chao Less -
Description:
Genomic changes in Mycoplasma pneumoniae caused by adaptation to environmental or ecologic pressures are poorly understood. We collected M. pneumoniae from children who had confirmed pneumonia in Taiwan during 2017-2020. We used whole-genome sequencing to compare these isolates with a worldwide collection of current and historical clinical strains for characterizing population structures. A phylogenetic tree for 284 strains showed that all sequenced strains consisted of 5 clades: T1-1 (sequence type [ST]1), T1-2 (mainly ST3), T1-3 (ST17), T2-1 (mainly ST2), and T2-2 (mainly ST14). We identified a putative recombination block containing 6 genes (MPN366‒371). Macrolide resistance involving 23S rRNA mutations was detected for each clade. Clonal expansion of macrolide resistance occurred mostly within subtype 1 strains, of which clade T1-2 showed the highest recombination rate and genome diversity. Functional characterization of recombined regions provided clarification of the biologic role of these recombination events in the evolution of M. pneumoniae.
Subjects:
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Anti-Bacterial Agents Child Drug Resistance, Bacterial Humans Macrolides Phylogeny Pneumonia, Mycoplasma Recombination, Genetic Rna, Ribosomal, 23S
Source:
Emerg Infect Dis. 2022; 28(1):111-117
Pubmed ID:
34932441
Pubmed Central ID:
PMC8714221
Document Type:
Journal Article
Place as Subject:
Taiwan
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:c5c8a420ce5342681689e03eeae2bfc98d86f7e983b898069fbcd809702bc8df
Download URL:
https://stacks.cdc.gov/view/cdc/113318/cdc_113318_DS1.pdf
File Type:

Supporting Files

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