CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Global Genome Diversity and Recombination in Mycoplasma pneumoniae
-
1 2022
-
-
Source: Emerg Infect Dis. 2022; 28(1):111-117
Details:
-
Alternative Title:Emerg Infect Dis
-
Personal Author:
-
Description:Genomic changes in Mycoplasma pneumoniae caused by adaptation to environmental or ecologic pressures are poorly understood. We collected M. pneumoniae from children who had confirmed pneumonia in Taiwan during 2017-2020. We used whole-genome sequencing to compare these isolates with a worldwide collection of current and historical clinical strains for characterizing population structures. A phylogenetic tree for 284 strains showed that all sequenced strains consisted of 5 clades: T1-1 (sequence type [ST]1), T1-2 (mainly ST3), T1-3 (ST17), T2-1 (mainly ST2), and T2-2 (mainly ST14). We identified a putative recombination block containing 6 genes (MPN366‒371). Macrolide resistance involving 23S rRNA mutations was detected for each clade. Clonal expansion of macrolide resistance occurred mostly within subtype 1 strains, of which clade T1-2 showed the highest recombination rate and genome diversity. Functional characterization of recombined regions provided clarification of the biologic role of these recombination events in the evolution of M. pneumoniae.
-
Subjects:
-
Source:
-
Pubmed ID:34932441
-
Pubmed Central ID:PMC8714221
-
Document Type:
-
Place as Subject:
-
Volume:28
-
Issue:1
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type: