SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020–March 2021

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Kleynhans, Jackie ; Tempia, Stefano ; Wolter, Nicole ; von Gottberg, Anne ; Bhiman, Jinal N. ; Buys, Amelia ; Moyes, Jocelyn ; McMorrow, Meredith L. ; Kahn, Kathleen ; Gómez-Olivé, F. Xavier ; Tollman, Stephen ; Martinson, Neil A. ; Wafawanaka, Floidy ; Lebina, Limakatso ; du Toit, Jacques ; Jassat, Waasila ; Neti, Mzimasi ; Brauer, Marieke ; Cohen, Cheryl
• Corporate Authors:
  for the PHIRST-C Group1
• Description:
  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may be underestimated because of limited access to testing. We measured SARS-CoV-2 seroprevalence in South Africa every 2 months during July 2020-March 2021 in randomly selected household cohorts in 2 communities. We compared seroprevalence to reported laboratory-confirmed infections, hospitalizations, and deaths to calculate infection-case, infection-hospitalization, and infection-fatality ratios in 2 waves of infection. Post-second wave seroprevalence ranged from 18% in the rural community children <5 years of age, to 59% in urban community adults 35-59 years of age. The second wave saw a shift in age distribution of case-patients in the urban community (from persons 35-59 years of age to persons at the extremes of age), higher attack rates in the rural community, and a higher infection-fatality ratio in the urban community. Approximately 95% of SARS-CoV-2 infections were not reported to national surveillance.
• Subjects:
  Adult Child Coronavirus Infections Covid-19 Humans Middle Aged Rural Population Sars-Cov-2 Seroepidemiologic Studies
• Source:
  Emerg Infect Dis. 2021; 27(12):3020-3029
• Pubmed ID:
  34477548
• Pubmed Central ID:
  PMC8632160
• Document Type:
  Journal Article
• Funding:
  WT_/Wellcome TrustUnited Kingdom/ ; U01IP001048/ACL/ACL HHSUnited States/
• Place as Subject:
  South Africa
• Location:
  Africa
• Volume:
  27
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:f752d11caf57c12c00bec0ad12de87d0f89f5c07d99259ed1c0072db86905625
• Download URL:
  https://stacks.cdc.gov/view/cdc/112626/cdc_112626_DS1.pdf
• File Type:
  [PDF - 2.61 MB ]