Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May–August 2020

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Stich, Maximilian ; Elling, Roland ; Renk, Hanna ; Janda, Aleš ; Garbade, Sven F. ; Müller, Barbara ; Kräusslich, Hans-Georg ; Fabricius, Dorit ; Zernickel, Maria ; Meissner, Peter ; Huzly, Daniela ; Grulich-Henn, Jürgen ; Haddad, Anneke ; Görne, Tessa ; Spielberger, Benedikt ; Fritsch, Linus ; Nieters, Alexandra ; Hengel, Hartmut ; Dietz, Andrea N. ; Stamminger, Thomas ; Ganzenmueller, Tina ; Ruetalo, Natalia ; Peter, Andreas ; Remppis, Jonathan ; Iftner, Thomas ; Jeltsch, Kathrin ; Waterboer, Tim ; Franz, Axel R. ; Hoffmann, Georg Friedrich ; Engel, Corinna ; Debatin, Klaus-Michael ; Tönshoff, Burkhard ; Henneke, Philipp
• Description:
  Resolving the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in households with members from different generations is crucial for containing the current pandemic. We conducted a large-scale, multicenter, cross-sectional seroepidemiologic household transmission study in southwest Germany during May 11-August 1, 2020. We included 1,625 study participants from 405 households that each had ≥1 child and 1 reverse transcription PCR-confirmed SARS-CoV-2-infected index case-patient. The overall secondary attack rate was 31.6% and was significantly higher in exposed adults (37.5%) than in children (24.6%-29.2%; p = <0.015); the rate was also significantly higher when the index case-patient was >60 years of age (72.9%; p = 0.039). Other risk factors for infectiousness of the index case-patient were SARS-CoV-2-seropositivity (odds ratio [OR] 27.8, 95% CI 8.26-93.5), fever (OR 1.93, 95% CI 1.14-3.31), and cough (OR 2.07, 95% CI 1.21-3.53). Secondary infections in household contacts generate a substantial disease burden.
• Subjects:
  Adult Child Coronavirus Infections Covid-19 Cross-Sectional Studies Humans Sars-Cov-2 Seroepidemiologic Studies
• Source:
  Emerg Infect Dis. 2021; 27(12):3009-3019
• Pubmed ID:
  34695369
• Pubmed Central ID:
  PMC8632156
• Document Type:
  Journal Article
• Place as Subject:
  Germany
• Location:
  Europe
• Volume:
  27
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:0220227f7076a90c703c8c2341d0e3d204ceb7386604eb3e58479863facae474
• Download URL:
  https://stacks.cdc.gov/view/cdc/112613/cdc_112613_DS1.pdf
• File Type:
  [PDF - 1.65 MB ]