Novel Filoviruses, Hantavirus, and Rhabdovirus in Freshwater Fish, Switzerland, 2017

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Hierweger, Melanie M. ; Koch, Michel C. ; Rupp, Melanie ; Maes, Piet ; Di Paola, Nicholas ; Bruggmann, Rémy ; Kuhn, Jens H. ; Schmidt-Posthaus, Heike ; Seuberlich, Torsten
• Description:
  European perch (Perca fluviatilis) are increasingly farmed as a human food source. Viral infections of European perch remain largely unexplored, thereby putting farm populations at incalculable risk for devastating fish epizootics and presenting a potential hazard to consumers. To address these concerns, we applied metatranscriptomics to identify disease-associated viruses in European perch farmed in Switzerland. Unexpectedly, in clinically diseased fish we detected novel freshwater fish filoviruses, a novel freshwater fish hantavirus, and a previously unknown rhabdovirus. Hantavirus titers were high, and we demonstrated virus in macrophages and gill endothelial cells by using in situ hybridization. Rhabdovirus titers in organ samples were low, but virus could be isolated on cell culture. Our data add to the hypothesis that filoviruses, hantaviruses, and rhabdoviruses are globally distributed common fish commensals, pathogens, or both. Our findings shed new light on negative-sense RNA virus diversity and evolution.
• Subjects:
  Animals Endothelial Cells Filoviridae Fish Diseases Fresh Water Hantavirus Humans Phylogeny Rhabdoviridae
• Source:
  Emerg Infect Dis. 2021; 27(12):3082-3091
• Pubmed ID:
  34808081
• Pubmed Central ID:
  PMC8632185
• Document Type:
  Journal Article
• Funding:
  HHSN272201800013C/AI/NIAID NIH HHSUnited States/
• Place as Subject:
  Switzerland
• Location:
  Europe
• Volume:
  27
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:52f39bedf5ad137fb0e64b3658211d4f5c0ec4ca37f8c249af713e67b8826e66
• Download URL:
  https://stacks.cdc.gov/view/cdc/112607/cdc_112607_DS1.pdf
• File Type:
  [PDF - 4.07 MB ]