Trends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Guo, Cosmos L.T. ; Kwong, Thomas N.Y. ; Mak, Joyce W.Y. ; Zhang, Lin ; Lui, Grace C.Y. ; Wong, Grace L.H. ; Ip, Margaret ; Yu, Jun ; Sung, Joseph J.Y. ; Wu, William K.K. ; Wong, Sunny H.
• Description:
  We conducted a territorywide survey to investigate the epidemiology, risk factors, and clinical outcomes of Clostridioides difficile infection (CDI) among hospitalized patients in Hong Kong. A total of 17,105 cases of CDI were identified, of which 15,717 (91.9%) were healthcare-associated and 1,025 (6.0%) were community-associated. Although CDI incidence increased substantially from 2006 to 2017, it plateaued in 2018 and 2019. The 30-day mortality rates decreased from 20.1% in 2015 to 16.8% in 2019, whereas the 60-day recurrence rates remained constant at ≈11% during the study period. Cross-correlation statistic showed significant correlations between incidence trend and overall antimicrobial drug use (r = 0.865, p<0.001), which has decreased as a result of an antibiotic stewardship program initiated in 2017. Our data suggest a turning point in C. difficile epidemiology that could be related to the changing pattern of antimicrobial drug use.
• Subjects:
  Clostridioides Difficile Clostridium Infections Humans Incidence
• Source:
  Emerg Infect Dis. 2021; 27(12):3036-3044
• Pubmed ID:
  34812719
• Pubmed Central ID:
  PMC8632188
• Document Type:
  Journal Article
• Place as Subject:
  Hong Kong
• Location:
  Asia
• Volume:
  27
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:3afaa7de218ea18ecd07dcdf0535c188994a5a4e5cd0cdf1ac87621b5f1ca428
• Download URL:
  https://stacks.cdc.gov/view/cdc/112597/cdc_112597_DS1.pdf
• File Type:
  [PDF - 1.31 MB ]