Details:

Alternative Title:
Neurotoxicology
Publisher's site:
http://dx.doi.org/10.1016/j.neuro.2021.05.017
Personal Author:
Racette, Brad A. ; Nelson, Gill ; Dlamini, Wendy W. ; Hershey, Tamara ; Prathibha, Pradeep ; ... More +
Racette, Brad A. ; Nelson, Gill ; Dlamini, Wendy W. ; Hershey, Tamara ; Prathibha, Pradeep ; Turner, Jay R. ; Checkoway, Harvey ; Sheppard, Lianne ; Nielsen, Susan Searles Less -
Description:
Objective:

To characterize the association between residential environmental manganese (Mn) exposure and depression and anxiety, given prior associations among occupationally-exposed workers.

Methods:

We administered the Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory (STAI) to 697 study participants in their preferred languages. These participants represented a population-based sample of residents aged ≥40 from two predominantly Black African communities in Gauteng province, South Africa: 605 in Meyerton, adjacent to a large Mn smelter, and 92 in Ethembalethu, a comparable non-exposed community. We investigated the associations between community (Meyerton vs. Ethembalethu) and severity of depression and anxiety, using linear regression, adjusting for age and sex. To document community-level differences in Mn exposure, we measured airborne PM2.5-Mn.

Results:

Meyerton residents had BDI scores 5.63 points (95% CI 3.07, 8.20) higher than Ethembalethu residents, with all questions contributing to this significant difference. STAI-state scores were marginally higher in Meyerton than Ethembalethu residents [2.12 (95% CI −0.17, 4.41)], whereas STAI-trait scores were more similar between the communities [1.26 (95% CI −0.82, 3.35)]. Mean PM2.5-Mn concentration was 203 ng/m3 at a long-term fixed site in Meyerton and 10 ng/m3 in Ethembalethu.

Conclusion:

Residence near Mn emission sources may be associated with greater depression symptomatology, and possibly current, but not lifetime, anxiety.


Subject:
[+]
Adult
Aged
Aged, 80 And Over
Anxiety
Depression
Environmental Exposure
Female
Humans
Independent Living
Male
Middle Aged
Psychiatric Status Rating Scales

Source:
Neurotoxicology. 85:222-233
Pubmed ID:
34087333
Pubmed Central ID:
PMC8635218
Document Type:
Journal Article
Funding:
R01 DK064832/DK/NIDDK NIH HHSUnited States/ ; R01 ES026246/ES/NIEHS NIH HHSUnited States/ ; R01 NS109487/NS/NINDS NIH HHSUnited States/ ; K24 ES017765/ES/NIEHS NIH HHSUnited States/ ; P42 ES023716/ES/NIEHS NIH HHSUnited States/ ; ... More +
R01 DK064832/DK/NIDDK NIH HHSUnited States/ ; R01 ES026246/ES/NIEHS NIH HHSUnited States/ ; R01 NS109487/NS/NINDS NIH HHSUnited States/ ; K24 ES017765/ES/NIEHS NIH HHSUnited States/ ; P42 ES023716/ES/NIEHS NIH HHSUnited States/ ; R01 ES026187/ES/NIEHS NIH HHSUnited States/ ; P30 NS098577/NS/NINDS NIH HHSUnited States/ ; R01 ES027696/ES/NIEHS NIH HHSUnited States/ ; R01 ES029524/ES/NIEHS NIH HHSUnited States/ ; R01 ES026891/ES/NIEHS NIH HHSUnited States/ ; R01 ES029509/ES/NIEHS NIH HHSUnited States/ ; R01 HD098255/HD/NICHD NIH HHSUnited States/ ; R01 OH011661/OH/NIOSH CDC HHSUnited States/ ; P01 AG055367/AG/NIA NIH HHSUnited States/ ; R01 ES025991/ES/NIEHS NIH HHSUnited States/ ; R01 ES029846/ES/NIEHS NIH HHSUnited States/ ; R01 HD070855/HD/NICHD NIH HHSUnited States/ ; R25 ES025503/ES/NIEHS NIH HHSUnited States/ ; K01 ES028295/ES/NIEHS NIH HHSUnited States/ ; R01 ES030937/ES/NIEHS NIH HHSUnited States/ Less -
Place as Subject:
South Africa
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:07167e72e3d4fef9681ddd7a58653eea6648a1c1ca3ac235bdfe4020da7c8b83
File Type:

Supporting Files

• 	nihms-1755597-f0001.gif	gif
  	nihms-1755597-f0001.jpg	jpeg
  	nihms-1755597.nxml	xml
  	NIHMS1755597-supplement-Supplemental_material.docx	docx

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