Depression and anxiety in a manganese-exposed community

Details

• Alternative Title:
  Neurotoxicology
• Personal Author:
  Racette, Brad A. ; Nelson, Gill ; Dlamini, Wendy W. ; Hershey, Tamara ; Prathibha, Pradeep ; Turner, Jay R. ; Checkoway, Harvey ; Sheppard, Lianne ; Nielsen, Susan Searles
• Description:
  Objective:
  
  To characterize the association between residential environmental manganese (Mn) exposure and depression and anxiety, given prior associations among occupationally-exposed workers.
  
  Methods:
  
  We administered the Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory (STAI) to 697 study participants in their preferred languages. These participants represented a population-based sample of residents aged ≥40 from two predominantly Black African communities in Gauteng province, South Africa: 605 in Meyerton, adjacent to a large Mn smelter, and 92 in Ethembalethu, a comparable non-exposed community. We investigated the associations between community (Meyerton vs. Ethembalethu) and severity of depression and anxiety, using linear regression, adjusting for age and sex. To document community-level differences in Mn exposure, we measured airborne PM2.5-Mn.
  
  Results:
  
  Meyerton residents had BDI scores 5.63 points (95% CI 3.07, 8.20) higher than Ethembalethu residents, with all questions contributing to this significant difference. STAI-state scores were marginally higher in Meyerton than Ethembalethu residents [2.12 (95% CI −0.17, 4.41)], whereas STAI-trait scores were more similar between the communities [1.26 (95% CI −0.82, 3.35)]. Mean PM2.5-Mn concentration was 203 ng/m3 at a long-term fixed site in Meyerton and 10 ng/m3 in Ethembalethu.
  
  Conclusion:
  
  Residence near Mn emission sources may be associated with greater depression symptomatology, and possibly current, but not lifetime, anxiety.
  
  
• Subjects:
  Adult Aged Aged, 80 And Over Anxiety Depression Environmental Exposure Female Humans Independent Living Male Middle Aged Psychiatric Status Rating Scales

  More +
• Source:
  Neurotoxicology. 85:222-233
• Pubmed ID:
  34087333
• Pubmed Central ID:
  PMC8635218
• Document Type:
  Journal Article
• Funding:
  R01 DK064832/DK/NIDDK NIH HHSUnited States/ ; R01 ES026246/ES/NIEHS NIH HHSUnited States/ ; R01 NS109487/NS/NINDS NIH HHSUnited States/ ; K24 ES017765/ES/NIEHS NIH HHSUnited States/ ; P42 ES023716/ES/NIEHS NIH HHSUnited States/ ; R01 ES026187/ES/NIEHS NIH HHSUnited States/ ; P30 NS098577/NS/NINDS NIH HHSUnited States/ ; R01 ES027696/ES/NIEHS NIH HHSUnited States/ ; R01 ES029524/ES/NIEHS NIH HHSUnited States/ ; R01 ES026891/ES/NIEHS NIH HHSUnited States/ ; R01 ES029509/ES/NIEHS NIH HHSUnited States/ ; R01 HD098255/HD/NICHD NIH HHSUnited States/ ; R01 OH011661/OH/NIOSH CDC HHSUnited States/ ; P01 AG055367/AG/NIA NIH HHSUnited States/ ; R01 ES025991/ES/NIEHS NIH HHSUnited States/ ; R01 ES029846/ES/NIEHS NIH HHSUnited States/ ; R01 HD070855/HD/NICHD NIH HHSUnited States/ ; R25 ES025503/ES/NIEHS NIH HHSUnited States/ ; K01 ES028295/ES/NIEHS NIH HHSUnited States/ ; R01 ES030937/ES/NIEHS NIH HHSUnited States/
• Place as Subject:
  South Africa
• Volume:
  85
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:07167e72e3d4fef9681ddd7a58653eea6648a1c1ca3ac235bdfe4020da7c8b83
• Download URL:
  https://stacks.cdc.gov/view/cdc/112224/cdc_112224_DS1.pdf
• File Type:
  [PDF - 534.38 KB ]