i
Hepatitis A Virus Incidence Rates and Biomarker Dynamics for Plasma Donors, United States
-
11 2021
Source: Emerg Infect Dis. 27(11):2718-2824 -
Alternative Title:Emerg Infect Dis
-
Personal Author:
-
Description:The United States is currently affected by widespread hepatitis A virus (HAV) outbreaks. We investigated HAV incidence rates among source plasma donors in the United States since 2016. Serial donations from HAV-positive frequent donors were analyzed for common biologic markers to obtain a detailed picture of the course of infection. We found a considerable increase in incidence rates with shifting outbreak hotspots over time. Although individual biomarker profiles were highly variable, HAV RNA typically had a high peak and a biphasic decrease and often remained detectable for several months. One donor had a biomarker pattern indicative of previous exposure. Our findings show that current HAV outbreaks have been spilling over into the plasma donor population. The detailed results presented improve our comprehension of HAV infection and related public health aspects. In addition, the capture of full RNA curves enables estimation of HAV doubling time.
-
Subjects:
-
Pubmed ID:34670659
-
Pubmed Central ID:PMC8544996
-
Document Type:
-
Place as Subject:
-
Collection(s):
-
Main Document Checksum:
-
File Type:
-
xml gif jpeg gif jpeg gif jpeg gif jpeg
Details:
Supporting Files
More +