Probability-Based Estimates of Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence and Detection Fraction, Utah, USA

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Samore, Matthew H. ; Looney, Adam ; Orleans, Brian ; Greene, Tom ; Seegert, Nathan ; Delgado, Julio C. ; Presson, Angela ; Zhang, Chong ; Ying, Jian ; Zhang, Yue ; Shen, Jincheng ; Slev, Patricia ; Gaulin, Maclean ; Yang, Mu-Jeung ; Pavia, Andrew T. ; Alder, Stephen C.
• Description:
  We aimed to generate an unbiased estimate of the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in 4 urban counties in Utah, USA. We used a multistage sampling design to randomly select community-representative participants >12 years of age. During May 4-June 30, 2020, we collected serum samples and survey responses from 8,108 persons belonging to 5,125 households. We used a qualitative chemiluminescent microparticle immunoassay to detect SARS-CoV-2 IgG in serum samples. We estimated the overall seroprevalence to be 0.8%. The estimated seroprevalence-to-case count ratio was 2.5, corresponding to a detection fraction of 40%. Only 0.2% of participants from whom we collected nasopharyngeal swab samples had SARS-CoV-2-positive reverse transcription PCR results. SARS-CoV-2 antibody prevalence during the study was low, and prevalence of PCR-positive cases was even lower. The comparatively high SARS-CoV-2 detection rate (40%) demonstrates the effectiveness of Utah's testing strategy and public health response.
• Subjects:
  Antibodies, Viral Coronavirus Infections Covid-19 Humans Probability Sars-Cov-2 Seroepidemiologic Studies
• Source:
  Emerg Infect Dis. 27(11):2786-2794
• Pubmed ID:
  34469285
• Pubmed Central ID:
  PMC8544980
• Document Type:
  Journal Article
• Funding:
  UL1 TR002538/TR/NCATS NIH HHSUnited States/
• Place as Subject:
  Utah
• Volume:
  27
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6663553aa89acb92def6f2ec2e3edd2387185b6c06eb171a90e2b69fb562511f
• Download URL:
  https://stacks.cdc.gov/view/cdc/111424/cdc_111424_DS1.pdf
• File Type:
  [PDF - 2.26 MB ]