Glycemic Control is Associated with Dyslipidemia Over Time in Youth with Type 2 Diabetes: the SEARCH for Diabetes in Youth Study

Details

• Alternative Title:
  Pediatr Diabetes
• Personal Author:
  Brady, Ryan P ; Shah, Amy S ; Jensen, Elizabeth T ; Stafford, Jeanette M ; D’Agostino, Ralph B ; Dolan, Lawrence M ; Knight, Lisa ; Imperatore, Giuseppina ; Turley, Christine B ; Liese, Angela D. ; Urbina, Elaine M ; Lawrence, Jean M ; Pihoker, Catherine ; Marcovina, Santica ; Dabelea, Dana
• Description:
  Background:
  
  Dyslipidemia has been documented in youth with type 2 diabetes. There is a paucity of studies examining dyslipidemia over time in youth with type 2 diabetes and associated risk factors.
  
  Objectives:
  
  To evaluate lipids at baseline and follow-up and associated risk factors in youth with type 2 diabetes.
  
  Methods:
  
  We studied 212 youth with type 2 diabetes at baseline and after an average of 7 years of follow-up in the SEARCH for Diabetes in Youth Study. Abnormal lipids were defined as HDL-C <35, LDL-C >100, or triglycerides >150 (all mg/dL). We evaluated participants for progression to abnormal lipids (normal lipids at baseline, abnormal at follow-up), regression (abnormal lipids at baseline, normal at follow-up), stable normal and stable abnormal lipids over time for HDL-C, LDL-C and triglycerides. Associations between HbA1c and adiposity over time (area under the curve, AUC) with progression and stable abnormal lipids were evaluated.
  
  Results:
  
  HDL-C progressed, regressed, was stable normal, and stable abnormal in 12.3%, 11.3%, 62.3%, and 14.2% of participants, respectively. Corresponding LDL-C percentages were 15.6%, 12.7%, 42.9% and 28.8% and triglycerides were 17.5%, 10.8%, 55.7% and 16.0%. Each 1% increase in HbA1c AUC was associated with a 13% higher risk of progression and stable abnormal triglycerides and a 20% higher risk of progression and stable abnormal LDL-C. Higher adiposity AUC was marginally (p=0.049) associated with abnormal HDL-C.
  
  Conclusions.
  
  Progression and stable abnormal LDL-C and triglycerides occur in youth with type 2 diabetes and are associated with higher HbA1c.
  
  
• Subjects:
  Adolescent Adult Article Child Cholesterol, HDL Cholesterol, LDL Diabetes Mellitus, Type 2 Disease Progression Dyslipidemia Dyslipidemias Female Glycated Hemoglobin A Glycemic Control Humans Male Risk Factors Triglycerides Type 2 Diabetes Young Adult Youth

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• Source:
  Pediatr Diabetes. 22(7):951-959
• Pubmed ID:
  34363298
• Pubmed Central ID:
  PMC8530941
• Document Type:
  Journal Article
• Funding:
  UC4 DK108173/DK/NIDDK NIH HHSUnited States/ ; U18 DP006131/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006134/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006138/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006139/DP/NCCDPHP CDC HHSUnited States/ ; R01 DK127208/DK/NIDDK NIH HHSUnited States/ ; U18 DP006136/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006133/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000246/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000247/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000248/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002709/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000254/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002708/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000244/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002710/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000250/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  22
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ff3460439582414ab62fb3ebaf51c9f2f615f03329d57800ccfb3905bf59a424
• Download URL:
  https://stacks.cdc.gov/view/cdc/110945/cdc_110945_DS1.pdf
• File Type:
  [PDF - 251.49 KB ]