Sleep Deficiency and Breast Cancer Risk Among Postmenopausal Women in the California Teachers Study (CTS)

Details

• Alternative Title:
  Cancer Causes Control
• Personal Author:
  Hurley, S ; Goldberg, D ; Behren, J Von ; DeHart, J Clague ; Wang, S ; Reynolds, P
• Description:
  Purpose:
  
  There is provocative, yet inconsistent, evidence that sleep deficiency may influence the development of breast cancer. The purpose of this study was to evaluate the risk of breast cancer associated with sleep deficiency among postmenopausal women in the California Teachers Study (CTS).
  
  Methods:
  
  We conducted a case-control study of 2,856 invasive breast cancer cases and 38,649 cancer-free controls, nested within the CTS. Self-administered questionnaires were used to ascertain several components of sleep deficiency, including quality, latency, duration, disturbance and use of sleep medications. Additionally, a Global Sleep Index (GSI) was created by summing the individual sleep components and categorizing into quartiles. Multivariable logistic regression analyses were used to estimate odds ratios and 95% confidence intervals (OR, 95% CI).
  
  Results:
  
  Increased breast cancer risks were associated with sleep deficiency. With the exception of duration, linear increases in risk were associated with all the other individual components of sleep deficiency (p-trend ≤0.002). The OR for the highest GSI quartile vs. lowest was 1.24, 95% CI: 1.12 – 1.38; p-trend <0.001).
  
  Conclusions:
  
  Sleep deficiency may be a risk factor for breast cancer. Additional prospective studies and those aimed at elucidating underlying mechanism are warranted.
  
  
• Subjects:
  Adult Aged Aged, 80 And Over Breast Neoplasms California Case-Control Studies Female Humans Longitudinal Studies Middle Aged Postmenopause Risk Factors Sleep Young Adult

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• Keywords:
  Breast Cancer Buprenorphine Case-Control Etiology Methadone Mortality Naltrexone Treatment
• Source:
  Cancer Causes Control. 31(12):1115-1128
• Pubmed ID:
  32981009
• Pubmed Central ID:
  PMC8519507
• Document Type:
  Journal Article
• Funding:
  HHSN261201800032C/CA/NCI NIH HHSUnited States/ ; HHSN261201800009C/CA/NCI NIH HHSUnited States/ ; HHSN261201800015I/CA/NCI NIH HHSUnited States/ ; P30-CA023100/CA/NCI NIH HHSUnited States/ ; HHSN261201800032I/CA/NCI NIH HHSUnited States/ ; P30 CA033572/CA/NCI NIH HHSUnited States/ ; HHSN261201800015C/CA/NCI NIH HHSUnited States/ ; U01 CA199277/CA/NCI NIH HHSUnited States/ ; UM1 CA164917/CA/NCI NIH HHSUnited States/ ; NU58DP006344/DP/NCCDPHP CDC HHSUnited States/ ; P30-CA033572/CA/NCI NIH HHSUnited States/ ; P30 CA023100/CA/NCI NIH HHSUnited States/ ; R01 CA077398/CA/NCI NIH HHSUnited States/ ; R01 CA207020/CA/NCI NIH HHSUnited States/ ; U01-CA199277/CA/NCI NIH HHSUnited States/ ; HHSN261201800009I/CA/NCI NIH HHSUnited States/ ; UM1-CA164917/CA/NCI NIH HHSUnited States/
• Volume:
  31
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:4c8f01145fc81310292db97cc42a7deb337c8943696164dc58f4633243db8a89f2dbc6d4063c7c7dc9eb4f4b54dc018b1806825387b244baf13b7c91ee7bb9ee
• Download URL:
  https://stacks.cdc.gov/view/cdc/110938/cdc_110938_DS1.pdf
• File Type:
  [PDF - 206.21 KB ]