Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19

Focosi, Daniele; Novazzi, Federica; Genoni, Angelo; Dentali, Francesco; Gasperina, Daniela Dalla; Baj, Andreina; Maggi, Fabrizio

doi:10.3201/eid2710.211538

i

Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19

Supporting Files Public Domain

10 2021
By Focosi, Daniele ; Novazzi, Federica ; Genoni, Angelo ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Focosi, Daniele ; Novazzi, Federica ; Genoni, Angelo ; Dentali, Francesco ; Gasperina, Daniela Dalla ; Baj, Andreina ; Maggi, Fabrizio
Description:

We report in vivo selection of a severe acute respiratory syndrome coronavirus 2 spike mutation (Q493R) conferring simultaneous resistance to bamlanivimab and etesivimab. This mutation was isolated from a patient who had coronavirus disease and was treated with these drugs.
Subjects:

Coronavirus Infections Covid-19 Humans Mutation Sars-Cov-2 Spike Glycoprotein, Coronavirus
Source:

Emerg Infect Dis. 27(10):2728-2731
Pubmed ID:

34314668
Pubmed Central ID:

PMC8462334
Document Type:

Journal Article
Volume:

27
Issue:

10
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:5a019f37bc34f6e4f82ce812e828954ed8bf665d422aec9c3eabc28e50d83b8c
Download URL:

https://stacks.cdc.gov/view/cdc/110453/cdc_110453_DS1.pdf
File Type:

[PDF - 1.12 MB ]

File Language:

English

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