SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Truffot, Aurélie ; Andréani, Julien ; Le Maréchal, Marion ; Caporossi, Alban ; Epaulard, Olivier ; Germi, Raphaele ; Poignard, Pascal ; Larrat, Sylvie
• Description:
  A 72-year-old immunocompromised man infected with severe acute respiratory syndrome coronavirus 2 received bamlanivimab monotherapy. Viral evolution was monitored in nasopharyngeal and blood samples by melting curve analysis of single-nucleotide polymorphisms and whole-genome sequencing. Rapid emergence of spike receptor binding domain mutations was found, associated with a compartmentalization of viral populations.
• Subjects:
  Aged Antibodies, Viral Coronavirus Infections Covid-19 Humans Immunocompromised Host Male Sars-Cov-2 Spike Glycoprotein, Coronavirus
• Source:
  Emerg Infect Dis. 27(10):2725-2728
• Pubmed ID:
  34352197
• Pubmed Central ID:
  PMC8462331
• Document Type:
  Journal Article
• Volume:
  27
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:829eab46f19873c807346a2e5ebe942adb140dbeff3e91f48ee302fa4574855c
• Download URL:
  https://stacks.cdc.gov/view/cdc/110452/cdc_110452_DS1.pdf
• File Type:
  [PDF - 2.45 MB ]