New Delhi Metallo-β-Lactamase–Producing Enterobacterales Bacteria, Switzerland, 2019–2020

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Findlay, Jacqueline ; Poirel, Laurent ; Kessler, Julie ; Kronenberg, Andreas ; Nordmann, Patrice
• Description:
  Carbapenemase-producing Enterobacterales (CPE) bacteria are a critical global health concern; New Delhi metallo-β-lactamase (NDM) enzymes account for >25% of all CPE found in Switzerland. We characterized NDM-positive CPE submitted to the Swiss National Reference Center for Emerging Antibiotic Resistance during a 2-year period (January 2019-December 2020) phenotypically and by using whole-genome sequencing. Most isolates were either Klebsiella pneumoniae (59/141) or Escherichia coli (52/141), and >50% were obtained from screening swabs. Among the 108 sequenced isolates, NDM-1 was the most prevalent variant, occurring in 56 isolates, mostly K. pneumoniae (34/56); the next most prevalent was NDM-5, which occurred in 49 isolates, mostly E. coli (40/49). Fourteen isolates coproduced a second carbapenemase, predominantly an OXA-48-like enzyme, and almost one third of isolates produced a 16S rRNA methylase conferring panresistance to aminoglycosides. We identified successful plasmids and global lineages as major factors contributing to the increasing prevalence of NDMs in Switzerland.
• Subjects:
  Beta-Lactamases Escherichia Coli Microbial Sensitivity Tests Rna, Ribosomal, 16S
• Source:
  Emerg Infect Dis. 27(10):2628-2637
• Pubmed ID:
  34545787
• Pubmed Central ID:
  PMC8462332
• Document Type:
  Journal Article
• Place as Subject:
  Switzerland
• Location:
  Europe
• Volume:
  27
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:4c98bfbc54547de09c736b937a8d2c1f253ac860bc4c4e037498ffd440b4d92c
• Download URL:
  https://stacks.cdc.gov/view/cdc/110445/cdc_110445_DS1.pdf
• File Type:
  [PDF - 2.49 MB ]