Predictors of Test Positivity, Mortality, and Seropositivity during the Early Coronavirus Disease Epidemic, Orange County, California, USA

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Parker, Daniel M. ; Bruckner, Tim ; Vieira, Verónica M. ; Medina, Catalina ; Minin, Vladimir N. ; Felgner, Philip L. ; Dratch, Alissa ; Zahn, Matthew ; Bartell, Scott M. ; Boden-Albala, Bernadette
• Description:
  We conducted a detailed analysis of coronavirus disease in a large population center in southern California, USA (Orange County, population 3.2 million), to determine heterogeneity in risks for infection, test positivity, and death. We used a combination of datasets, including a population-representative seroprevalence survey, to assess the actual burden of disease and testing intensity, test positivity, and mortality. In the first month of the local epidemic (March 2020), case incidence clustered in high-income areas. This pattern quickly shifted, and cases next clustered in much higher rates in the north-central area of the county, which has a lower socioeconomic status. Beginning in April 2020, a concentration of reported cases, test positivity, testing intensity, and seropositivity in a north-central area persisted. At the individual level, several factors (e.g., age, race or ethnicity, and ZIP codes with low educational attainment) strongly affected risk for seropositivity and death.
• Subjects:
  Coronavirus Infections Covid-19 Epidemics Humans Sars-Cov-2 Seroepidemiologic Studies
• Source:
  Emerg Infect Dis. 27(10):2604-2618
• Pubmed ID:
  34545792
• Pubmed Central ID:
  PMC8462316
• Document Type:
  Journal Article
• Place as Subject:
  California
• Location:
  North America
• Volume:
  27
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:72f425aca395d0ddabf87dd36dde32fd9f8ac6e31b12b08f6886b713d1f2cbe8
• Download URL:
  https://stacks.cdc.gov/view/cdc/110423/cdc_110423_DS1.pdf
• File Type:
  [PDF - 8.19 MB ]