Multicenter Epidemiologic Study of Coronavirus Disease–Associated Mucormycosis, India

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Patel, Atul ; Agarwal, Ritesh ; Rudramurthy, Shivaprakash M. ; Shevkani, Manoj ; Xess, Immaculata ; Sharma, Ratna ; Savio, Jayanthi ; Sethuraman, Nandini ; Madan, Surabhi ; Shastri, Prakash ; Thangaraju, Deepak ; Marak, Rungmei ; Tadepalli, Karuna ; Savaj, Pratik ; Sunavala, Ayesha ; Gupta, Neha ; Singhal, Tanu ; Muthu, Valliappan ; Chakrabarti, Arunaloke
• Corporate Authors:
  MucoCovi Network3
• Description:
  During September-December 2020, we conducted a multicenter retrospective study across India to evaluate epidemiology and outcomes among cases of coronavirus disease (COVID-19)-associated mucormycosis (CAM). Among 287 mucormycosis patients, 187 (65.2%) had CAM; CAM prevalence was 0.27% among hospitalized COVID-19 patients. We noted a 2.1-fold rise in mucormycosis during the study period compared with September-December 2019. Uncontrolled diabetes mellitus was the most common underlying disease among CAM and non-CAM patients. COVID-19 was the only underlying disease in 32.6% of CAM patients. COVID-19-related hypoxemia and improper glucocorticoid use independently were associated with CAM. The mucormycosis case-fatality rate at 12 weeks was 45.7% but was similar for CAM and non-CAM patients. Age, rhino-orbital-cerebral involvement, and intensive care unit admission were associated with increased mortality rates; sequential antifungal drug treatment improved mucormycosis survival. The COVID-19 pandemic has led to increases in mucormycosis in India, partly from inappropriate glucocorticoid use.
• Subjects:
  Antifungal Agents Coronavirus Infections Covid-19 Humans Mucormycosis Pandemics Retrospective Studies Sars-Cov-2
• Source:
  Emerg Infect Dis. 27(9):2349-2359
• Pubmed ID:
  34087089
• Pubmed Central ID:
  PMC8386807
• Document Type:
  Journal Article
• Place as Subject:
  India
• Location:
  Asia
• Volume:
  27
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:549686b7565be4dd448f8254a50c7f4bac2f323e307a69b46144ae508023f31a
• Download URL:
  https://stacks.cdc.gov/view/cdc/109721/cdc_109721_DS1.pdf
• File Type:
  [PDF - 2.32 MB ]