HIV Infection as Risk Factor for Death among Hospitalized Persons with Candidemia, South Africa, 2012–2017

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Govender, Nelesh P. ; Todd, Jim ; Nel, Jeremy ; Mer, Mervyn ; Karstaedt, Alan ; Cohen, Cheryl
• Corporate Authors:
  for GERMS-SA1
• Description:
  We determined the effect of HIV infection on deaths among persons >18 months of age with culture-confirmed candidemia at 29 sentinel hospitals in South Africa during 2012-2017. Of 1,040 case-patients with documented HIV status and in-hospital survival data, 426 (41%) were HIV-seropositive. The in-hospital case-fatality rate was 54% (228/426) for HIV-seropositive participants and 37% (230/614) for HIV-seronegative participants (crude odds ratio [OR] 1.92, 95% CI 1.50-2.47; p<0.001). After adjusting for relevant confounders (n = 907), mortality rates were 1.89 (95% CI 1.38-2.60) times higher among HIV-seropositive participants than HIV-seronegative participants (p<0.001). Compared with HIV-seronegative persons, the stratum-specific adjusted mortality OR was higher among HIV-seropositive persons not managed in intensive care units (OR 2.27, 95% CI 1.47-3.52; p<0.001) than among persons who were (OR 1.56, 95% CI 1.00-2.43; p = 0.05). Outcomes among HIV-seropositive persons with candidemia might be improved with intensive care.
• Subjects:
  Candidemia Hiv Infections Humans Risk Factors
• Source:
  Emerg Infect Dis. 27(6):1607-1615
• Pubmed ID:
  34014153
• Pubmed Central ID:
  PMC8153852
• Document Type:
  Journal Article
• Place as Subject:
  South Africa
• Volume:
  27
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:91c881b0a7ab5f44a09bb148770daae74e519972daf6abbae7c49a1d48dc0fcd
• Download URL:
  https://stacks.cdc.gov/view/cdc/106896/cdc_106896_DS1.pdf
• File Type:
  [PDF - 1.02 MB ]