Rocky Mountain Spotted Fever in a Large Metropolitan Center, Mexico–United States Border, 2009–2019

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Zazueta, Oscar E. ; Armstrong, Paige A. ; Márquez-Elguea, Adriana ; Hernández Milán, Néstor Saúl ; Peterson, Amy E. ; Ovalle-Marroquín, Diego F. ; Fierro, Maria ; Arroyo-Machado, Rodolfo ; Rodriguez-Lomeli, Moises ; Trejo-Dozal, Guillermo ; Paddock, Christopher D.
• Description:
  Epidemic levels of Rocky Mountain spotted fe­­­ver (RMSF) have persisted in Mexicali, Mexico, since the initial outbreak was first reported in December 2008. We compared clinical and epidemiologic data of cases in Mexicali during 2009–2019 between patients with an IgG titer reactive with Rickettsia rickettsii bacteria by indirect immunofluorescence antibody (IFA) assay and those who demonstrated DNA of R. rickettsii in a whole blood sample when tested by PCR. We identified 4,290 patients with clinical and epidemiologic features compatible with RMSF; of these, 9.74% tested positive by IFA and 8.41% by PCR. Overall, 140 patients died (11-year case-fatality rate 17.97%). Substantial differences in the frequency of commonly recognized clinical characteristics of RMSF were identified between PCR-positive and IFA-positive cases. The Mexicali epidemic is unique in its size and urban centralization. Cases confirmed by PCR most accurately reflect the clinical profile of RMSF.
• Subjects:
  Animals Rhipicephalus Sanguineus Rickettsia Rickettsii Rocky Mountain Spotted Fever
• Source:
  Emerg Infect Dis. 27(6):1567-1576
• Pubmed ID:
  34014151
• Pubmed Central ID:
  PMC8153879
• Document Type:
  Journal Article
• Place as Subject:
  Mexico ; United States
• Volume:
  27
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:0eca5f256e850fa8cb4cf6a58c9a627789042f9435fc9590380a80132c410921
• Download URL:
  https://stacks.cdc.gov/view/cdc/106878/cdc_106878_DS1.pdf
• File Type:
  [PDF - 1.68 MB ]