Upsurge of Conjugate Vaccine Serotype 4 Invasive Pneumococcal Disease Clusters Among Adults Experiencing Homelessness in California, Colorado, and New Mexico

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Beall, Bernard ; Walker, Hollis ; Tran, Theresa ; Li, Zhongya ; Varghese, Jasmine ; McGee, Lesley ; Li, Yuan ; Metcalf, Benjamin J. ; Gierke, Ryan ; Mosites, Emily ; Chochua, Sopio ; Pilishvili, Tamara
• Description:
  After 7-valent pneumococcal conjugate vaccine introduction in the United States in 2000, invasive pneumococcal disease (IPD) due to serotype 4 greatly decreased in children and adults. Starting in 2013, serotype 4 IPD incidence increased among adults within 3 of 10 Active Bacterial Core surveillance sites. Of 325 serotype 4 cases among adults in 2010-2018, 36% were persons experiencing homelessness (PEH); incidence of serotype 4 IPD among PEH was 100-300 times higher than in the general population within these 3 areas. Genome sequencing for isolates recovered 2015-2018 (n = 246), revealed that increases in serotype 4 IPD were driven by lineages ST10172, ST244, and ST695. Within each lineage, clusters of near-identical isolates indicated close temporal relatedness. Increases in serotype 4 IPD were limited to Colorado, California, and New Mexico, with highest increases among PEH, who were at increased risk for exposure to and infections caused by these strains.
• Subjects:
  Adult Humans Ill-Housed Persons Incidence New Mexico Pneumococcal Infections Pneumococcal Vaccines Serogroup Streptococcus Pneumoniae Vaccines, Conjugate
• Keywords:
  Conjugate Vaccines Persons Experiencing Homelessness Pneumococcal Polysaccharide Serotype 4
• Source:
  J Infect Dis. 223(7):1241-1249
• Pubmed ID:
  32798216
• Pubmed Central ID:
  PMC8108119
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Place as Subject:
  California ; Colorado ; New Mwxico
• Volume:
  223
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:711dae1a4c2e31f03ff34cd63dcbb1f754d1955de3a3a771d9f0fc9d8fe87e6a
• Download URL:
  https://stacks.cdc.gov/view/cdc/106092/cdc_106092_DS1.pdf
• File Type:
  [PDF - 890.30 KB ]