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Toxicological Profile for Hexachlorobutadiene: March 2021
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March 2021
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Description:Hexachlorobutadiene (C4Cl6; CAS No. 87-68-3) is a colorless liquid with a turpentine-like odor with an odor threshold of approximately 1 ppm. The main source of hexachlorobutadiene in the United States is its production as a byproduct of chlorinated hydrocarbon synthesis.
Low levels of hexachlorobutadiene can be detected in air, water, and sediment. Atmospheric levels of hexachlorobutadiene in rural and urban air samples typically range from 2 to 11 ppt, with a mean value of 2–3 ppt. Higher levels can be detected at areas near industrial and chemical waste disposal sites and production sites. Hexachlorobutadiene is infrequently detected in ambient waters, but has been detected in drinking water at levels of 2–3 ppt. Sediments contain higher levels of hexachlorobutadiene than the waters from which they were obtained. Foodstuffs generally do not contain detectable levels of hexa- chlorobutadiene, except for fish in which concentrations of 0.1–4.7 mg/kg have been reported. Thus, exposure can occur through ingestion of contaminated water or food or inhalation of contaminated air.
Hexachlorobutadiene has been detected in human adipose tissue and blood samples, although general population monitoring data are not available.
Version History
Date Description
March 2021 Final toxicological profile released
December 2019 Draft for public comment toxicological profile released
December 2012 Addendum to the toxicological profile released
May 1994 Final toxicological profile released
CS274127-A
tp42.pdf
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