Details:

Alternative Title:
Environ Sci Pollut Res Int
Publisher's site:
http://dx.doi.org/10.1007/s11356-020-12135-7|10.1016/J.ACA.2012.04.009|10.1016/J.ENVRES.2018.01.033|10.1021/acs.est.9b06587|10.1016/J.ENVRES.2019.01.018|10.1007/BF00383132|10.1002/sim.3222|10.3390/ijerph17155408|10.1021/tx00033a001|10.1007/s00420-010-0520-8|10.13075/ijomeh.1896.00086|10.1080/1047322X.1990.10389587|10.1007/s00420-002-0335-3|10.1016/J.ETAP.2015.07.018|10.1093/ajh/1.2.124|10.1039/a903039e|10.1021/tx000230r|10.1007/s004200050016|10.1007/s00420-003-0474-1|10.1152/ajpendo.00585.2012|10.1016/J.CBI.2018.12.011|10.1093/ntr/nty089|10.1186/s12889-016-3939-3|10.1080/13547500500333648|10.1007/978-1-4020-9160-5_183|10.2478/v10001-009-0028-1|10.1539/joh.43.92|10.2486/indhealth.2014-0070|10.1007/BF00381473|10.1007/BF00381474|10.1016/J.CBI.2003.06.003|10.1007/s002040000197|10.1096/fj.13-233320|10.1016/j.chroma.2004.03.057|10.1289/ehp.8850|10.1007/s00216-015-8719-x|10.1097/JOM.0000000000000983|10.1007/BF00572236|10.1002/rcm.3659|10.1007/s00204-018-2219-7|10.1016/0304-3894(87)85039-2|10.1021/tx00020a006|10.1007/s11882-014-0431-y|10.1016/J.ENVINT.2015.12.003|10.1093/toxsci/kfx076
Personal Author:
Kenwood, Brandon M. ; Bagchi, Pritha ; Zhang, Luyu ; Zhu, Wanzhe ; Chambers, David M. ; ... More +
Kenwood, Brandon M. ; Bagchi, Pritha ; Zhang, Luyu ; Zhu, Wanzhe ; Chambers, David M. ; Blount, Benjamin C. ; De Jesús, Víctor R. Less -
Description:
Methylcarbamoyl mercapturic acid (MCAMA, N-acetyl-S-(N-methylcarbamoyl)-L-cysteine) is a urinary metabolite of N,N-dimethylformamide and methyl isocyanate, which are volatile organic compounds that are harmful to humans. N,N-dimethylformamide exposure causes liver damage, and methyl isocyanate inhalation damages the lining of the respiratory tract, which can increase risk of chronic obstructive pulmonary disease and asthma. This study characterizes urinary MCAMA levels in the US population and explores associations of MCAMA concentrations with select demographic and environmental factors. We used liquid chromatography tandem mass spectrometry to measure MCAMA in urine collected from study participants ≥ 12 years old (N = 8272) as part of the National Health and Nutrition Examination Survey 2005-2006 and 2011-2016. We produced multiple regression models with MCAMA concentrations as the dependent variable and sex, age, fasting time, race/ethnicity, diet, and cigarette smoking as independent variables. Cigarette smokers and nonsmokers had median urinary MCAMA concentrations of 517 μg/g creatinine and 127 μg/g creatinine, respectively. Sample-weighted multiple regression analysis showed that MCAMA was positively associated with serum cotinine (p < 0.0001). Compared to non-exposed participants (serum cotinine ≤ 0.015 ng/mL), presumptive exposure to second-hand tobacco smoke (serum cotinine > 0.015-≤ 10 ng/mL and 0 cigarettes smoked per day) was associated with 20% higher MCAMA (p < 0.0001). Additionally, smoking 1-10 cigarettes per day was associated with 261% higher MCAMA (p < 0.0001), smoking 11-20 cigarettes per day was associated with 357% higher MCAMA (p < 0.0001), and smoking > 20 cigarettes per day was associated with 416% higher MCAMA (p < 0.0001). These findings underscore the strong association of tobacco smoke exposure with urinary MCAMA biomarker levels.
Subject:
[+]
Acetylcysteine Article Biomarkers Child Cotinine Dimethylformamide Humans Isocyanates Methylcarbamoyl Mercapturic Acid Methyl Isocyanate N,N-Dimethylformamide N-acetyl-S-(N-methylcarbamoyl)-L-cysteine Nutrition Surveys Tobacco Smoke Exposure Tobacco Smoke Pollution Volatile Organic Compounds
Source:
Environ Sci Pollut Res Int. 28(13):16781-16791
Pubmed ID:
33398732
Pubmed Central ID:
PMC7979481
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHSUnited States/
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e6dce9fd28dbd4925873e775a3c85c9c39e157190d474928073ac0eb72ec767d
Download URL:
https://stacks.cdc.gov/view/cdc/104376/cdc_104376_DS1.pdf
File Type:

Supporting Files

• 	nihms-1659761-f0001.gif	gif
  	nihms-1659761-f0001.jpg	jpeg
  	nihms-1659761.nxml	xml
  	NIHMS1659761-supplement-Supplementary_tables.docx	docx

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